Abstract
The catecholaminergic systems appear to mediate some of physical dependence of opiates.1 For example, Clonidine, a drug that decreases noradrenergic activity, prevents behavior induced by morphine withdrawal.2 An increase in the noradrenergic neuron firing rate in the locus coeruleus (LC) 3 and an increase in the turnover of noradrenaline (NA) have been reported during naloxone-precipitated morphine withdrawal.4
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Noda, Y., Nabeshima, T. (2002). The Mechanisms of Morphine Dependence and It’s Withdrawal Syndrome: Study in Mutant Mice. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_94
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DOI: https://doi.org/10.1007/978-1-4757-3538-3_94
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