The Mechanisms of Morphine Dependence and It’s Withdrawal Syndrome: Study in Mutant Mice

Catecholamines and addiction
  • Yukihiro Noda
  • Toshitaka Nabeshima
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


The catecholaminergic systems appear to mediate some of physical dependence of opiates.1 For example, Clonidine, a drug that decreases noradrenergic activity, prevents behavior induced by morphine withdrawal.2 An increase in the noradrenergic neuron firing rate in the locus coeruleus (LC) 3 and an increase in the turnover of noradrenaline (NA) have been reported during naloxone-precipitated morphine withdrawal.4


Tyrosine Hydroxylase Locus Coeruleus Withdrawal Syndrome Morphine Withdrawal CREB Binding Protein 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Yukihiro Noda
  • Toshitaka Nabeshima
    • 1
  1. 1.Department of Neuropsychopharmacology and Hospital PharmacyNagoya University Graduate School of MedicineShowa-ku, NagoyaJapan

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