Activation of Hypocretin Neurons and Sleep

  • Véronique Fabre
  • Patrice Bourgin
  • J. Gregor Sutcliffe
  • Luis de Lecea
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


The hypocretins (hcrt-1 and hcrt-2), also called orexins (OX-A and OX-B), are neuropeptides first described because of their restricted expression in a subset of hypothalamic neurons (de Lecea et al., 1998). The hypocretin precursor gives raise to two peptides named hypocretin-1 and hypocretin-2, after their sequence similarity to secretin and the prominent expression of preprohypocretin mRNA in the hypothalamus. Independently, Sakurai et al. (1998) identified identical peptides from brain extracts through their ability to bind and activate orphan G-protein coupled receptors. These authors also showed that when injected into the brain ventricles, the peptides stimulate food intake, thus they named them orexins, from the Greek word orexis (appetite).


Cholera Toxin Lateral Hypothalamus Arcuate Nucleus Noradrenergic Neuron HYPOCRETIN Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Véronique Fabre
  • Patrice Bourgin
  • J. Gregor Sutcliffe
  • Luis de Lecea
    • 1
  1. 1.Department of Molecular Biology, MB10The Scripps Research InstituteLa JollaUSA

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