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Catecholamine Research pp 365–368Cite as

BDNF-Dependent Behavioral Sensitization in Hemiparkinsonian Rats

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 53))

Abstract

A diverse role for BDNF (Brain-derived neurotrophic factor) has been inferred from observations that it is anterogradely transported, released upon neuron depolarization and triggers rapid intracellular signals.1’2 Converging evidence implicates the D3 receptor (D3R) in the physiopathology and treatment of various neuropsychiatrie disorders including Parkinson’s disease, 3, 4 schizophrenia, 5, 6 and drug addiction.7, 8 In a rat model of Parkinson’s disease, obtained by unilateral destruction of dopamine neurons by 6- hydroxydopamine (6-OHDA), D3R expression is decreased in the shell part of nucleus accumbens (AccSh) of the denervated side3, by deprivation of BDNF9 synthesized by dopamine neurons. Repeated administration of levodopa triggers D3R overexpression in the denervated striatum3, which is responsible for the development of behavioral sensitization to levodopa. Progressive enhancement of levodopa-induced rotations are blocked by a preferential D3R antagonist3 and induced by a selective partial D3R agonist.8 Here we show that BDNF is also responsible for induction of D3R overexpression in 6- OHDA-lesioned rats, and thereby for behavioral sensitization.

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Authors and Affiliations

  1. Unité de Neurobiologie et Pharmacologie Moléculaire, INSERM U 109, 75014, Paris, France

    Olivier Guillin, Nathalie Griffon, Jean-Charles Schwartz & Pierre Sokoloff

  2. Université René Descartes, 75006, Paris, France

    Jorge Diaz

Authors
  1. Olivier Guillin
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  2. Jorge Diaz
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  3. Nathalie Griffon
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  4. Jean-Charles Schwartz
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  5. Pierre Sokoloff
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Editor information

Editors and Affiliations

  1. Fujita Health University, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

  2. Nagoya University, Nagoya, Japan

    Toshitaka Nabeshima

  3. Vanderbilt University, Nashville, Tennessee, USA

    Richard McCarty

  4. National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA

    David S. Goldstein

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© 2002 Springer Science+Business Media New York

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Guillin, O., Diaz, J., Griffon, N., Schwartz, JC., Sokoloff, P. (2002). BDNF-Dependent Behavioral Sensitization in Hemiparkinsonian Rats. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_87

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  • DOI: https://doi.org/10.1007/978-1-4757-3538-3_87

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3388-1

  • Online ISBN: 978-1-4757-3538-3

  • eBook Packages: Springer Book Archive

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