Abstract
The ability to respond selectively to certain aspects of the environment, and filter-out others that are irrelevant to the current behavioral plan, is critical for goal-directed behavior. At the same time, behavior must be flexible and adaptive, so as to quickly adjust to new imperative, or unexpected events. Thus, successful behavior in both animals and humans requires the capacity for both selective responding in a stable environment, and rapid adaptive responding in a changing environment. Our recent work on the locus coeruleus-norepinephrine (LC-NE) system has led us to hypothesize that it plays a central role in regulating this balance between focused vs. flexible responding.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aston-Jones, G., Rajkowski, J. and Kubiak, P., 1997, Conditioned responses of monkey locus coeruleus neurons anticipate acquisition of discriminative behavior in a vigilance task, Neuroscience 80: 697–715.
Aston-Jones, G., Rajkowski, J., Kubiak, P. and Alexinsky, T., 1994, Locus coeruleus neurons in the monkey are selectively activated by attended stimuli in a vigilance task, J. Neurosci. 14: 4467–4480.
Carter, C. S., Braver, T. S., Barch, D. M, Botvinick, M. M., Noll, D. and Cohen, J. D., 1998, Anterior cingulate cortex, error detection, and the online monitoring of performance, Science 280: 747–749.
Christie, M. J. and Jelinek, H. F., 1993, Neuroscience 56: 129–137.
Foote, S. L., Bloom, F. E. and Aston-Jones, G., 1983, Nucleus locus ceruelus; new evidence of anatomical and physiological specificity, Physiol. Rev. 63: 844–914.
Ishimatsu, M. and Williams, J. T., 1996, Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions, J. Neurosci. 16: 5196–5204.
Usher, M, Cohen, J. D., Rajkowski, J., Kubiak, P. and Aston-Jones, G., 1999, The role of locus coeruleus in the regulation of cognitive performance, Science 283: 549–554.
Waterhouse, B. D. and Woodward, D. J., 1980, Interaction of norepinephrine with cerebrocortical activity evoked by stimulation of somatosensory afferent pathways in the rat, Exp Neurol 67: 11–34.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Aston-Jones, G., Rajkowski, J., Cohen, J. (2002). Role of the Locus Coeruleus-Norepinephrine System in Attention and Behavioral Flexibility. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_85
Download citation
DOI: https://doi.org/10.1007/978-1-4757-3538-3_85
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-3388-1
Online ISBN: 978-1-4757-3538-3
eBook Packages: Springer Book Archive