Dopaminergic Effects on Acquisition and Consolidation: A Microdialysis Study

  • Masahiko Nomura
  • Kiyoyuki Maruki
  • Koji Hori
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


While experimental animals are learning on a schedule-controlled discrimination learning task in an operant type Skinner box, one may examine the relationship between learning ability and neurochemical changes by measuring the content of various neurotransmitters using a microdialysis method. In particular, some of the catecholamines have much closer correlations with learning ability compared to other neurotransmitters. Among the catecholamines, dopamine and its metabolites in amygdala, hippocampus, thalamus, and cortex are increased during learning performance. Dopamine appears to play an important role in the acquisition and consolidation stages of learning.


Discrimination Learning Lever Press Microdialysis Study Anterior Thalamus Consolidation Stage 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Masahiko Nomura
    • 1
  • Kiyoyuki Maruki
    • 2
  • Koji Hori
    • 3
  1. 1.Department of PhysiologySaitama Medical SchoolSaitamaJapan
  2. 2.Department of PsychiatrySaitama Medical SchoolSaitamaJapan
  3. 3.Department of PsychologyRikkyo UniversityTokyoJapan

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