Monoamines and Fear-Related Behaviors

  • Mitsuhiro Yoshioka
  • Machiko Matsumoto
  • Kiyoshi Mori
  • Hiroko Togashi
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


The mesocortical dopamine (DA) neuronal system has been reported to show regional differences in sensitivity to various pharmacological and behavioral manipulations. For instance, cortical DA neuronal activity was facilitated following application of atypical antipsychotic drugs (Broderick and Piercey, 1998) or anxiogenic agent (Bradberry et al., 1991), but nigrostriatal and mesolimbic DA systems were not influenced by these drugs. Physiological stimuli such as tail-shock stress (Abercrombie et al., 1989) or prolonged handling (Feenstra et al., 1998) produced greater enhancement of DA release in the prefrontal cortex (PFC) than in the striatum and/or the nucleus accumbens. Recently, we have demonstrated that DA release in the PFC was enhanced by conditioned fear stress (CFS), an animal model of anxiety which is regarded as psychological stress without physical stimuli (Fanselow, 1980), whereas any changes of striatal DA levels were not found by exposure to CFS. These regional differences of characteristics of DA neurons may be pivotal for understanding the mechanism underlying the pathophysiology of DA neuronal function. The PFC receives not only dopaminergic inputs from the ventral tegmental area but also reciprocal projections of other neuronal systems. Among these neurotransmitters, serotonin (5-HT) has been focused on the regulation of DA neuronal activity in both cell bodies and terminal regions based on clinical and neurochemical studies (Broderick and Piercey, 1998; Saito et al, 1996).


Nucleus Accumbens Ventral Tegmental Area Neuronal System Atypical Antipsychotic Drug Anxiolytic Drug 
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  1. Abercrombie E. D., Keefe K. A., DiFrischia D. S., and Zigmond M. J., 1989, Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex. J. Neurochem. 52: 1655–1658.PubMedCrossRefGoogle Scholar
  2. Bradberry C. W., Lory J. D., and Roth R. J. , 1991, The anxiogenic-carboline FG 7142 selectively increases dopamine release in the rat prefrontal cortex as measured by microdialysis. J. Neurochem. 56: 748–752.PubMedCrossRefGoogle Scholar
  3. Broderick P. A., and Piercey M. F ., 1998, Clozapine, haloperidol, and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolimbic, and nigrostriatal dopamine and serotonin release. J. Neural Transm. 105: 749–767.PubMedCrossRefGoogle Scholar
  4. Fanselow M. S., 1980, Conditional and unconditional components of postshock freezing. Pavlov J. Biol Sci. 15: 177–180.PubMedGoogle Scholar
  5. Feenstra M. G. P., Botterblom M. H. A., and van Uum J. F. M, 1998, Local activation of metabotropic glutamate receptors inhibits the handling-induced increased release of dopamine in the nucleus accumbens but not that of dopamine or noradrenaline in the prefrontal cortex: Comparison with inhibition of ionotropic receptors. J. Neurochem. 70: 1104–1113.PubMedCrossRefGoogle Scholar
  6. Handley, S.L., Mithani, S., 1984, Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ‘fear’-motivated behaviour. Naunyn-Schmiedeberg’s Arch Pharmacol. 327: 1–5.CrossRefGoogle Scholar
  7. Saito, H., Matsumoto, M., Togashi, H., Yoshioka, M., 1996, Functional interaction between serotonin and other neuronal system focus on in vivo microdialysis studies. Jpn. J. Pharmacol. 70: 203–225PubMedCrossRefGoogle Scholar
  8. Yoshioka, M., Matsumoto, M., Togashi, H., Saito, H., 1995, Effects of conditioned fear stress 5-HT release in the rat prefrontal cortex. Pharmacol. Biochem. Behav. 51: 515–519.PubMedCrossRefGoogle Scholar
  9. Yoshioka, M., Matsumoto, M., Togashi, H., Saito H., 1996, Effect of conditioned fear stress on dopamine release in the rat prefrontal cortex. Neuroscience Lett. 209: 201–203.CrossRefGoogle Scholar
  10. Wright, I.K., Heaton, M., Upton, N., Marsden, CA., 1992, Comparison of acute and chronic treatment of various serotonergic agents with those of diazepam and idazoxan in the rat elevated X-maze. Psychopharmacol. 107: 405–414.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Mitsuhiro Yoshioka
  • Machiko Matsumoto
  • Kiyoshi Mori
  • Hiroko Togashi
    • 1
  1. 1.Department of PharmacologyHokkaido University School of MedicineSapporoJapan

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