Involvement of Ionotropic Glutamate Receptors and Nitric Oxide in DOPA-Induced Depressor Responses in the Nucleus Tractus Solitarii

  • Y. Goshima
  • K. Yamanashi
  • T. Miyamae
  • Y. Sasaki
  • M. Maeda
  • H. Hirano
  • Y. Misu
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

L-Dihydroxyphenylalanine (DOPA) is proposed to be a neurotransmitter for the primary baroreceptor afferents terminating in the nucleus tractus solitarii (NTS),1 and it produces glutamate-like depressor responses when microinjected into the NTS of anesthetized rats. Little is known about the mechanism of such an excitatory action of DOPA. In striata, exogenous DOPA induces glutamate release and endogenous DOPA is a causal factor for the ischemic glutamate release and resultant delayed neuronal death.2 In the present study, we tried to clarify whether glutamate receptors and/or nitric oxide (NO), an important modulator for central cardiovascular regulation, are involved in the DOPA-induced cardiovascular responses in the NTS of anesthetized rats.

Keywords

Nitric Oxide Glutamate Receptor Cardiovascular Response Nucleus Tractus Solitarii Ionotropic Glutamate Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Y. Goshima
    • 1
  • K. Yamanashi
    • 1
  • T. Miyamae
    • 1
  • Y. Sasaki
    • 1
  • M. Maeda
    • 2
  • H. Hirano
    • 3
  • Y. Misu
    • 4
  1. 1.Yokohama City University School of MedicineYokohamaJapan
  2. 2.Wakayama Medical CollegeWakayamaJapan
  3. 3.University of Occupational and Environmental HealthKitakyusyuJapan
  4. 4.Shinobu HospitalFukushimaJapan

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