α1D-Adrenergic Receptor Knockout Mice Display Impaired Vascular Contractile Response to Catecholamines
The sympathetic nervous system plays an important role in regulating the tone of the peripheral circulation, and hence in the control of blood pressure. Catecholamines cause vascular smooth muscle contraction by activating α1-adrenergic receptors (α1-ARs).1) Recent extensive efforts has been spent in classifying the three known α1AR subtypes (α1A, α1B, and α1D) via molecular cloning2 and pharmacological analyses3; however, still the contribution of each α1-AR subtype in catecholamine-induced physiological responses has not been well characterized.
KeywordsContractile Response Receptor Knockout Mouse Aortic Segment Adrenergic Receptor Antagonist Vascular Smooth Muscle Contraction
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