Hypothalamo-Sympathetic Control of Cellular Immunity

  • Toshihiko Katafuchi
  • Zhichun Shi
  • Sachiko Take
  • Tetsuro Hori
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


In addition to the presence of β- and α-adrenergic receptors on lymphocytes and other immunocompetent cells (Sanders et al., 2001), anatomical studies have revealed the direct contact between tyrosine hydroxylase positive nerve terminals and lymphocytes in the spleen (Bellinger et al., 2001). However, the effects of noradrenaline (NA) on the immune responses in vitro are rather complicated depending on Th predominance, and the dose of NA (for review see Hori et al., 1995; Madden, 2001).


Sodium Salicylate Lateral Hypothalamic Area Natural Killer Cytotoxicity Splenic Nerve Splenic Natural Killer Cell 
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  1. Sanders, V. M., Kasprowicz, D. J., Kohm, A. P., and Swanson, M.A., 2001, Neurotransmitter receptors on lym phocytes and other lymphoid cells, in: Psychoneuroimmunology, third edition, R. Ader, D. L. Feiten, and N. Cohen, eds., Academic Press, San Diego, pp. 161–196.Google Scholar
  2. Bellinger, D. L., Lorton, D., Lubahn, C., and Feiten, D.L., 2001, Innervation of lymphoid organs—Association of nerves with cells of the immune system and their implications in disease, in: Psychoneuroimmunology, third edition, R. Ader, D. L. Feiten, and N. Cohen, eds., Academic Press, San Diego, pp. 55–111.Google Scholar
  3. Hori, T., Katafuchi, T., Take, S., Shimizu, N., and Niijima, A., 1995, The autonomic nervous system as a communication channel between the brain and the immune system, Neuroimmunomodulation 2: 203–215.PubMedCrossRefGoogle Scholar
  4. Madden, K. S., 2001, Catecholamines, sympathetic nerves, and immunity, in: Psychoneuroimmunology, third edition, R. Ader, D. L. Feiten, and N. Cohen, eds., Academic Press, San Diego, pp. 197–216.Google Scholar
  5. Wan, W., Vriend, C. Y., Wetmore, L., Gartner, J. G., Greenberg, A. H., and Nance, D. M., 1993, The effects of stress on splenic immune function are mediated by the splenic nerve. Brain Res. Bull. 30: 101–105.PubMedCrossRefGoogle Scholar
  6. Shimizu, N., Kaizuka, Y., Hori, T., and Nakane, H., 1996, Immobilization increases norepinephrine release an d reduces NK cytotoxicity in spleen of conscious rat, Am. J. Physiol. 271: R537–R544.Google Scholar
  7. Irwin, M., Vale, W., and Rivier, C., 1990, Central corticotropin-releasing factor mediates the suppressive effect of stress on natural killer cytotoxicity, Endocrinology 126: 2837–2844.PubMedCrossRefGoogle Scholar
  8. Ichijo, T., Katafuchi, T., and Hori, T., 1994, Central administration of interleukin-1β enhances splenic sympa thetic nerve activity in rats, Brain Res. Bull. 34:547–553.PubMedCrossRefGoogle Scholar
  9. Katafuchi, T., Ichijo, T., and Hori, T., 1997, Sequential relationship between actions of CRF and PGE2 in the brain on splenic sympathetic nerve activity in rats, J. Auton. Nerv. Syst. 67: 200–206.PubMedCrossRefGoogle Scholar
  10. Katafuchi, T., Take, S., and Hori, T., 1993a, Roles of sympathetic nervous system in the suppression of cytotox icity of splenic natural killer cells in the rat, J. Physiol. (Lond.) 465: 343–357.Google Scholar
  11. Sundar, S. K., Becker, K. J., Cierpial, M. A., Carpenter, M. D., Rankin, L. A., Fleener, S. L., Ritochie, J. C., Simson, P. E., and Weiss, J. M., 1989, Intracerebroventricular infusion of interleukin 1 rapidly decreases peripheral cellular immune responses, Proc. Natl. Acad. Sci. USA 86: 6398–6402.PubMedCrossRefGoogle Scholar
  12. Sundar, S. K., Cierpial, M. A., Kilts, C., Ritchie, J. C., and Weiss, J. M., 1990, Brain IL-1-induced immunosup pression occurs through activation of both pituitary-adrenal axis and sympathetic nervous system by corticotropin-releasing factor, J. Neurosci. 10: 3701–3706.PubMedGoogle Scholar
  13. Irwin, M., 1993, Brain corticotropin-releasing hormone- and interleukin-1β-induced suppression of specific antibody production, Endocrinology 133: 1352–1360.PubMedCrossRefGoogle Scholar
  14. Brown, R., Li, Z., Vriend, C. Y., Nirula, R., Janz, L., Falk, J., Nance, D. M., Dyck, D. G., and Greenberg, A. H., 1991, Suppression of splenic macrophage interleukin-1 secretion following intracerebroventricular injection of interleukin-1β, Cell. Immunol. 132: 84–93.PubMedCrossRefGoogle Scholar
  15. Take, S., Mori, T., Katafuchi, T., and Hori, T., 1993, Central interferonot inhibits natural killer cytotoxicity through sympathetic innervation, Am. J. Physiol. 265: R453–R459.Google Scholar
  16. Take, S., Uchimura, D., Kanemitsu, Y., Katafuchi, T., and Hori, T., 1995, Interferon-α acts at the preoptic hy pothalamus to reduce natural killer cytotoxicity in rats, Am. J. Physiol. 268: R1406–R1410.Google Scholar
  17. Katafuchi, T., Ichijo, T., Take, S., and Hori, T., 1993b, Hypothalamic modulation of natural killer cell activity in rats, J. Physiol. (Lond.) 471: 209–221.Google Scholar
  18. Ando, T, Ichijo, T, Katafuchi, T, and Hori, T., 1995, Intracerebroventricular injection of prostaglandin E2 increases splenic sympathetic nerve activity in rats, Am. J. Physiol. 269: R662–R668.Google Scholar
  19. Hopkins, S. J., and Rothwell, N. J., 1995, Cytokines and the nervous system. I. Expression and recogni tion, Trends Neurosci. 18: 83–88.PubMedCrossRefGoogle Scholar
  20. Minami, M., Kuraishi, Y., Yamaguchi, T., Nakai, S., Hirai, Y., and Satoh, M., 1991, Immobilization stress in duces interleukin-1βmRN A in the rat hypothalamus, Neurosci. Lett. 123: 254–256.PubMedCrossRefGoogle Scholar
  21. Saperstein, A., Brand, H., Audhya, T., Nabriski, D., Hutchinson, B., Rosenzweig, S., and Hollander, C. S., 1992, Interleukin 1β mediates stress-induced immunosuppression via corticotropin-releasing factor, Endocrinology 130: 152–158.PubMedCrossRefGoogle Scholar
  22. Shi, Z., Katafuchi, T., Take, S., and Hori, T., 1997, Responses of splenic sympathetic nerve activity in rats to chemical stimulation of the hypothalamus, Jpn. J. Physiol 47 (suppl. 2): S227, 699.Google Scholar
  23. Nakashima, T., Hori, T., Kuriyama, K., and Matsuda, T., 1988, Effects of interferon-a on the activity of preop tic thermosensitive neurons in tissue slices, Brain Res. 454: 361–367.PubMedCrossRefGoogle Scholar
  24. Saphier, D., Feldman, S., 1986, Effects of stimulation of the preoptic area on hypothalamic paraventricular nucleus unit activity and corticosterone secretion in freely moving rats, Neuroendocrinology 42: 167–173.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Toshihiko Katafuchi
  • Zhichun Shi
  • Sachiko Take
  • Tetsuro Hori
    • 1
  1. 1.Department of Integrative Physiology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

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