Biosynthesis of Neuromelanin and Melanin: The Potential Involvement of Macrophage Inhibitory Factor and Dopachrome Tautomerase as Rescue Enzymes
This chapter summarizes our recent studies on the regulation of melanin synthesis, a chemical pathway which bears a striking resemblance to that proposed to be involved in neuromelanin production from Dopamine (DN).1 Two key enzymes, DOPAchrome tautomerase (DCT) and macrophage migration inhibitory factor (MIF), have analogous catalytic actions in those biosynthetic pathways which may be linked to their roles as survival enzymes in melanocytes and in catecholaminergic neurons, respectively.
KeywordsElectron Paramagnetic Resonance Migration Inhibitory Factor Melanin Synthesis Macrophage Migration Inhibitory Factor Melanin Production
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