Biosynthesis of Neuromelanin and Melanin: The Potential Involvement of Macrophage Inhibitory Factor and Dopachrome Tautomerase as Rescue Enzymes

  • Jun Matsunaga
  • Patrick A. Riley
  • Francisco Solano
  • Vincent J. Hearing
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


This chapter summarizes our recent studies on the regulation of melanin synthesis, a chemical pathway which bears a striking resemblance to that proposed to be involved in neuromelanin production from Dopamine (DN).1 Two key enzymes, DOPAchrome tautomerase (DCT) and macrophage migration inhibitory factor (MIF), have analogous catalytic actions in those biosynthetic pathways which may be linked to their roles as survival enzymes in melanocytes and in catecholaminergic neurons, respectively.


Electron Paramagnetic Resonance Migration Inhibitory Factor Melanin Synthesis Macrophage Migration Inhibitory Factor Melanin Production 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Jun Matsunaga
    • 1
  • Patrick A. Riley
    • 2
  • Francisco Solano
    • 3
  • Vincent J. Hearing
    • 1
  1. 1.Laboratory of Cell Biology, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  2. 2.Gray Laboratory Cancer Research TrustMount Vernon HospitalNorthwoodUK
  3. 3.Department of Biochemistry, Molecular Biology B and ImmunologyUniversity of Murcia School of MedicineMurciaSpain

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