Differential Regulation of Myocardial Cell Apoptosis by α- and β-Adrenergic Pathways

  • Koji Hasegawa
  • Eri Iwai-Kanai
  • Shigetake Sasayama
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


The apoptosis of cardiac myocytes may play a role in the development of heart failure.1–3 Norepinephrine is one of factors activated in heart failure4 and can induce myocardial cell apoptosis in culture.5 However, it is unknown if α- and β-adrenergic pathways coordinately or differentially regulate apoptosis and if this apoptotic pathway utilizes common or cell type-specific apoptotic signals.


Cardiac Myocytes Brain Natriuretic Peptide Atrial Natriuretic Peptide Adrenergic Pathway PCI2 Cell 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Koji Hasegawa
    • 1
  • Eri Iwai-Kanai
    • 1
  • Shigetake Sasayama
    • 1
  1. 1.Department of Cardiovascular Medicine, Graduate School of MedicineKyoto UniversityKyotoJapan

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