Abstract
One of the promising approaches for the treatment or prevention of neurodegenerative diseases, including Parkinson’s disease, is to investigate the molecular basis of neurodegeneration or neuronal death and elucidate possible therapeutic molecular targets. The Bcl-2 family of proteins is a major cell death regulator and is implicated in determining the survival or death of neurons under physiological as well as pathological conditions. I will provide an overview of the functions of this family of proteins and their targets, and will discuss a possible molecular approach for the prevention of neurodegenerative diseases.
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Refernces (our works cited)
Tsujimoto, Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria. Genes to Cells 3:697–707, 1998
Tsujimoto, Y. and Shimizu, S.: Bcl-2 family: Life-or-death switch, FEBS lett. 466: 6–10, 2000
Tsujimoto, Y Prevention of neuronal cell death by Bcl-2. Results Probi. Cell Differ. 24: 137–55, 1998
Iwahashi, H., Eguchi, Y, Yasuhara, N., Hanafusa, T., Matsuzawa, Y and Tsujimoto, Y: Synergistic antiapoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy. Nature 390: 413–417, 1997
Shimizu, S., Eguchi, Y, Kamiike, W., Waguri, S., Uchiyama, Y, Matsuda, H. and Tsujimoto, Y: Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: Possible common steps in apoptosis and necrosis. Oncogene 12: 2045–2050, 1996.
Eguchi, Y, Shimizu, S. and Tsujimoto, Y: Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. 57: 1835–1840, 1997
Eguchi, Y, Srinivasan, A., Tomaselli, K. J., Shimizu, S. and Tsujimoto Y, ATP-dependent steps in apoptotic signal transduction. Cancer Res. 59: 2174–2181, 1999
Shimizu, S., Narita, M. and Tsujimoto T, Y Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399: 483–487, 1999
Tsujimoto, Y. and Shimizu, S. VDAC regulation by the Bcl-2 family of proteins. Cell Death Diff. 7: 1174–1181,2000
Shimizu, S., Shinohara, Y. and Tsujimoto, Y. Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator. Oncogene 19: 4309–4318, 2000
Shimizu, S., Matsuoka, Y, Shinohara, Y, Yoneda, Yand Tsujimoto, Y Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J. Cell Biol. 152: 237–250 (2001)
Shimizu, S., Konishi, A., Kodama, T. and Tsujimoto, Y.: BH4 domain of anti-apoptotic Bcl-2 family members closes VDAC, and inhibits apoptotic mitochondrial changes and cell death. Proc. Natl. Acad. Sci. USA 97: 3100–3105, 2000
Kusano, H., Shimizu, S., Koya, R.-C, Fujita, H., Kamada, S., Kuzumaki, N. and Tsujimoto Y, Y Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene 19: 4807–4814, 2000
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Tsujimoto, Y. (2002). Regulation of Cell Death by the Bcl-2 Family of Proteins. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_58
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DOI: https://doi.org/10.1007/978-1-4757-3538-3_58
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