Adrenergic Control of Microglia
Microglial cells, which are responsible for immunological surveillance of the brain, may intimately interact with neurons, since they become activated at the earliest phase of neuropathological processes in response to even minor damage of neurons.1 Some diffusible factors from neurons may be important in the rapid functional changes in microglial cells, because most microglial cells are normally surrounded by astrocytes.2 Among the diffusible factors, neurotransmitters such as norepinephrine (NE) are possible candidates responsible for regulating the interactions between neurons and microglial cells. As has been suggested on the basis of electron microscopic study, noradrenergic synapses seem designed to release NE into the extracellular fluid so that they cannot be confined to the vicinity of the synaptic cleft. Microglial cells are known to respond to adrenergic agonists.3 Yet, the expression of adrenergic receptors (AR) has not been identified. Therefore, we first aimed to reveal what types of ARs were expressed in cultured rat microglial cells by RT-PCR in the present study.
KeywordsElectron Spin Resonance Microglial Cell Adrenergic Receptor Synaptic Cleft Adrenergic Agonist
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