Mechanisms Underlying Neuronal Death Induced by Activated Microglia

  • Hiroshi Nakanishi
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Microglia are considered to usually support the survival of neurons. However, in some pathological circumstances, microglia are activated and believed to kill neurons by producing neurotoxic and pro-inflammatory molecules such as nitric oxide, reactive oxygen intermediates and tumor necrosis factor-a. In Parkinson’s disease, an activation of microglia has an essentially important pathogenic implication, because the substantia nigra has a high density of microglia. In fact, activated microglia have been shown to induce degeneration of dopaminergic neurons both in vitro1 and in vivo studies2. Despite the clinical importance, the precise intracellular mechanism for neuronal death triggered by activated microglia is currently unknown.


Neuronal Death Reactive Oxygen Intermediate Lysosomal Storage Disease Neuronal PC12 Cell Pathological Circumstance 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Hiroshi Nakanishi
    • 1
  1. 1.Laboratory of Oral Aging Science, Division of Oral Biological Sciences, Faculty of Dental SciencesKyushu UniversityFukuokaJapan

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