Neuronal Gene Regulation by the Neural — Restrictive Silencer (NRS)

Is the catecholaminergic system excluded from control by NRS?
  • Nozomu Mori
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Neural restrictive silencer (NRS) is a 22-bp-long cell type-specific transcriptional silencer element that is found in a variety of neural-specific genes.1,2 NRS represses transcription in non-neuronal cells, thereby allowing gene expression only in neurons. The sequence-specific DNA-binding protein that recognizes NRS (NRSF, also named REST) is expressed essentially in undifferentiated neuronal precursors and non-neuronal cells and functions as a transcriptional repressor.3 NRSF represents the first example of a vertebrate silencer factor that regulates a large battery of neuronal phenotype-specific genes, and therefore may function as a general negative regulator of neuronal terminal differentiation. However, in contrast to what was originally thought, recent evidence suggests that NRS is found in many genes involved in the cholinergic, GABAergic, and glutamatergic neuronal transmission, but may not be evident in the genes that relate to monoaminergic neurotransmission. Here I would like to discuss the possibility that NRS represses neurons to acquire monoaminergic function and that the role of NRS could be somehow limited in monoaminergic or catecholaminergic systems.


Tyrosine Hydroxylase Neuronal Differentiation Atrial Natriuretic Peptide Phenyl Ethanolamine Catecholaminergic System 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Nozomu Mori
    • 1
    • 2
  1. 1.Department of Molecular GeneticsNational Institute for Longevity Sciences (NILS)Oobu, AichiJapan
  2. 2.Program of “Protecting the Brain”CREST, JSTOobu, AichiJapan

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