Role of Presynaptic Dopamine D2-Like Receptors in Midbrain Dopaminergic System

  • Toshihiko Momiyama
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Information has been accumulated little by little on the modulatory role of dopamine (DA) in central synaptic transmission. The studies during these several years have reported modulation of central synaptic transmission by D1-like DA receptors located on the presynaptic terminals of GABAergic or glutamatergic fibres.1 More recently, presynaptic D2-like receptor-mediated modulation of central synaptic transmission has been analyzed using electrophysiological techniques. In this chapter, the roles of presynaptic D2-like DA receptors in midbrain DA systems are reviewed, focused mainly on non-NMDA glutamatergic synaptic transmission onto DA-containing neurons in the ventral tegmental area (VTA), and GABAergic transmission onto cholinergic interneurons in the striatum.


Ventral Tegmental Area Presynaptic Terminal Excitatory Transmission Inhibitory Postsynaptic Current GABAergic Terminal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    T. Momiyama, in: Slow Synaptic Responses and Modulation, edited by K. Kuba, H. Higashida, D.A. Brown and T. Yoshioka (Springer-Verlag Tokyo 2000), pp. 410–415.CrossRefGoogle Scholar
  2. 2.
    E. Koga and T. Momiyama, Presynaptic dopamine D2-like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones, J. Physiol. (Lond.) 523 (1), 163–173 (2000).CrossRefGoogle Scholar
  3. 3.
    T. Momiyama and E. Koga, Dopamine D2-like receptors selectively block N-type Ca2+ channels to reduce GABA release onto rat striatal cholinergic interneurones, J. Physiol. (Lond.) 533 (2), 479–492 (2001).CrossRefGoogle Scholar
  4. 4.
    T. Takahashi and A. Momiyama, Different types of calcium channels mediate central synaptic transmission, Nature 366, 156–158(1993).PubMedCrossRefGoogle Scholar
  5. 5.
    D.B. Wheeler, A. Randall and R.W. Tsien, Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission, Science 264, 107–111 (1994).PubMedCrossRefGoogle Scholar
  6. 6.
    S. Iwasaki, A. Momiyama, O.D. Uchitel and T. Takahashi, Developmental changes in calcium channel types mediating central synaptic transmission, J. Neurosci. 20, 59–65 (2000).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Toshihiko Momiyama
    • 1
  1. 1.Division of Cerebral StructureNational Institute for Physiological SciencesMyodaiji, OkazakiJapan

Personalised recommendations