The Vesicular Monoamine Transporters (VMATs): Role in the Chemical Coding of Neuronal Transmission and Monoamine Storage in Amine-Handling Immune and Inflammatory Cells

  • L. E. Eiden
  • B. Schütz
  • M. Anlauf
  • C. Depboylu
  • M. K.-H. Schäfer
  • E. Weihe
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Monoamines can act as neurotransmitters, hormones, autocrine and paracrine factors, or autacoids. How they function depends on the locations of the cells that synthesize and store them, and the stimuli that release them. All amine transmitters are first sequestered in a storage vesicle or granule, from which they are secreted from the cell. This requires specific transporters that reside on the vesicle. All of the vesicular transporters for classical neurotransmitters inferred to exist as individual proteins based on functional studies, have been cloned and characterized in a detailed molecular way over the last ten years (see Table 1). As a result, an understanding has developed that the role of these transporters in the chemical coding of neurotransmission is dynamic, and a novel view of what constitutes a neurotransmitter phenotype for a given neuron has emerged. The purpose of this contribution is to highlight recent progress from our laboratories and others in understanding the evolution of vesicular transporter structure, transport properties and cell-specific expression, as these relate to the physiological and regulatory functions of mammalian monoamine-containing*** neuronal, endocrine, and hematopoietic cells.

Keywords

Synaptic Vesicle Vesicular Transporter Eccrine Sweat Gland Vesicular Monoamine Transporter Nucleus Tractus Solitarious 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • L. E. Eiden
    • 1
  • B. Schütz
    • 2
  • M. Anlauf
    • 2
  • C. Depboylu
    • 2
  • M. K.-H. Schäfer
    • 2
  • E. Weihe
    • 1
  1. 1.Section on Molecular NeuroscienceNational Institute of Mental Health, NIHBethesdaUSA
  2. 2.Institute of Anatomy and Cell BiologyPhilipps-UniversitätMarburgGermany

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