Interaction between Glutamate and Monoamines
Electrophysiological studies revealed that in the prefrontal cortex(PFC), dopamine has an inhibitory action via dopamine D1 receptor,1 and serotonin has an excitatory action via 5-HT2A receptor,2 on glutamatergic neurotransmission. The changes in activity of glutamatergic pyramidal neurons play an important role in pathogenesis of phencyclidine(PCP)-induced psychosis3 or schizophrenia.4 However, neurochemical basis for the modulation of glutamatergic neurotransmission in the PFC is not well known. In this chapter, we present data on the effects of stimulation or blockade of dopamine D1 receptor, and blockade of 5-HT2A receptor or dopamine D4 receptor on basal levels or PCP-induced increases in extracellular concentrations of glutamate.
KeywordsGlutamate Level Apical Dendrite Glutamatergic Neurotransmission High Performance Liquid Chromatographic Determination Glutamatergic Pyramidal Neuron
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