Abstract
Although old MAO inhibitors, nonselective and irreversible MAO inhibitors, have antidepressive effects, they had serious side effects, such as hepatotoxicity caused by a hydrazine moiety, the cheese effect and orthostatic hypotension. Due to these adverse events, classical MAO inhibitors with a hydrazine moiety are no longer used clinically.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bonhomme, N. and Esposito, E., 1998, Involvement of serotonin and dopamine in the mechanism of action of novel antidepressant drugs: a review. J. Clin. Psychopharmacol., 18, 447–54.
Curet, O., Sontag, N., Aubin, N., Marc, C., Jegham, S., Puech, F., Burnier, P., George, P., Scatton, B., 2000, Biochemical profile of SL25.1131 a novel mixed and reversible MAO-A/B inhibitor. 30th Soc. Neurosci.Abs., 666.2, 2000 (New Orleans).
Fahn, S. and Chouinard, S., 1998, Experience with tranylcypromine in early Parkinson’s disease, J Neural Transm [Suppl]. 52: 49–61.
Suzuki T, Akaike N, Ueno K, Tanaka Y, Himori, N., 1995, MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in mice. Pharmacology, 50: 357–62.
Speiser, Z., Mayk, A., Eliash, S., Cohen, S., 1999, Studies with rasagiline, a MAO-B inhibitor, in experimental focal ischemia in the rat, J. Neural Transm., 106: 593–606.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Iwata, N. (2002). Current Status of New MAO-A/B Inhibitor Development. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_33
Download citation
DOI: https://doi.org/10.1007/978-1-4757-3538-3_33
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-3388-1
Online ISBN: 978-1-4757-3538-3
eBook Packages: Springer Book Archive