Current Status of New MAO-A/B Inhibitor Development

  • N. Iwata
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Although old MAO inhibitors, nonselective and irreversible MAO inhibitors, have antidepressive effects, they had serious side effects, such as hepatotoxicity caused by a hydrazine moiety, the cheese effect and orthostatic hypotension. Due to these adverse events, classical MAO inhibitors with a hydrazine moiety are no longer used clinically.

Keywords

Inhibitor Development Inhibit Tyrosine Hydroxylase Cheese Effect Hydrazine Moiety Inhibitor Tranylcypromine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • N. Iwata
    • 1
  1. 1.Science Information Co., Ltd.TokyoJapan

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