Current Status of New MAO-A/B Inhibitor Development
Although old MAO inhibitors, nonselective and irreversible MAO inhibitors, have antidepressive effects, they had serious side effects, such as hepatotoxicity caused by a hydrazine moiety, the cheese effect and orthostatic hypotension. Due to these adverse events, classical MAO inhibitors with a hydrazine moiety are no longer used clinically.
KeywordsInhibitor Development Inhibit Tyrosine Hydroxylase Cheese Effect Hydrazine Moiety Inhibitor Tranylcypromine
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