Current Status of New MAO-A/B Inhibitor Development

  • N. Iwata
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Although old MAO inhibitors, nonselective and irreversible MAO inhibitors, have antidepressive effects, they had serious side effects, such as hepatotoxicity caused by a hydrazine moiety, the cheese effect and orthostatic hypotension. Due to these adverse events, classical MAO inhibitors with a hydrazine moiety are no longer used clinically.


Inhibitor Development Inhibit Tyrosine Hydroxylase Cheese Effect Hydrazine Moiety Inhibitor Tranylcypromine 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • N. Iwata
    • 1
  1. 1.Science Information Co., Ltd.TokyoJapan

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