In Vivo and in Vitro Functions of Two Types of Mao

  • Jean C. Shih
  • Kevin Chen
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Monoamine oxidase (MAO) A and B have selective substrate and inhibitor specificity. MAO A and B knock-out mice exhibit distinct neurotransmitter metabolism and behavior, suggesting that these two isoenzymes have distinct functions in vivo. These two isoenzymes are coded by different cDNAs with 70% amino acid identity. Interestingly, Isoleucine 335 in MAO A and the corresponding amino acid in MAO B, tyrosine 326, determine the substrate and inhibitor selectivity in vitro.


Monoamine Oxidase Mitochondrial Monoamine Oxidase Norrie Disease Liver Monoamine Oxidase Inhibitor Clorgyline 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Jean C. Shih
    • 1
  • Kevin Chen
    • 2
  1. 1.Department of Molecular Pharmacology and Toxicology, School of Pharmacy and Department of Cell and Neurobiology, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of Molecular Pharmacology and Toxicology, School of PharmacyUniversity of Southern CaliforniaLos AngelesUSA

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