Cell-Type Specific Gene Regulation of Tyrosine Hydroxylase in the Central Nervous System

  • Yoshinori Shimizu
  • Shuei Sugama
  • Byung Pil Cho
  • Tong H. Joh
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Since 1964 when Nagatsu, Levitt and Udenfriend1 identified and partially characterized tyrosine hydroxylase (TH) from the rat adrenal gland as the rate limiting enzyme in the catecholamine (CA) biosynthetic pathway, TH has become one of the most studied enzymes in biochemistry, pharmacology and neuroscience. It has been also widely used as a marker protein for catecholamine neurons in the studies on human brain diseases that include behavioral (Schizophrenia, depression, drug abuse, etc.) and neurodegenerative disorders (Parkinson’s disease).


Tyrosine Hydroxylase Adrenal Medulla Restraint Stress Tyrosine Hydroxylase Gene Inducible cAMP Early Repressor 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Yoshinori Shimizu
    • 1
  • Shuei Sugama
    • 1
  • Byung Pil Cho
    • 1
  • Tong H. Joh
    • 1
  1. 1.The Burke Medical Research Institute, Department of Neurology and NeuroscienceWeill Medical College of Cornell UniversityWhite PlainsUSA

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