L-Dopa Uptake and Decarboxylation in the Brain

  • Kunio Kitahama
  • Ryohachi Arai
  • Michel Geffard
  • Nobuyuki Karasawa
  • Ikuko Nagatsu
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

L-dihydroxyphenylalanine (L-DOPA) therapy has been well accepted in order to improve extrapyramidal motor disturbance in Parkinson disease, and the uptake and metabolism of loaded DOPA as a precursor of dopamine (DA) in the brain has been studied, using autoradiography and high-resolution positron emission tomography (PET). However, no detailed anatomical information has been provided. It is known that L-DOPA is transformed by a second step catecholamine-synthesizing enzyme, aromatic L-amino acid decarboxylase (AADC). In the present study, we examined the localization of this enzyme, and elucidated in what neuronal structures L-DOPA is converted to DA, using immunohistochemistry in conjunction with the antisera, anti-DA as well as anti-AADC.

Keywords

Dorsal Raphe Nucleus Sodium Metabisulfite Nickel Ammonium Positron Emission Tomographic Study Detailed Anatomical Information 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kunio Kitahama
    • 1
  • Ryohachi Arai
    • 2
  • Michel Geffard
    • 3
  • Nobuyuki Karasawa
    • 4
  • Ikuko Nagatsu
    • 4
  1. 1.Neurobiologie des états de sommeils et d’éveilINSERM U480Lyon Cedex 08France
  2. 2.Department of AnatomyShiga University of Medical ScienceJapan
  3. 3.INSERMTalenceFrance
  4. 4.Department of AnatomyFujita Health UniversityJapan

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