Abstract
Sympathetic nerve excitation stimulates β-adrenergic receptors on cardiac myocytes by release of noradrenaline, leading to an increase in the contractility. This cardiostimulant effect is mediated by an increase in Ca2+ permeability resulted from cyclic AMP-dependent phosphorylation of voltage-gated ion channels (Figure 1). Opening of phosphorylated L-type Ca2+ channels and tetrodotoxin-sensitive Na+ channels results in a transient intracellular Ca2+ concentration increase ([Ca2+]i transient) which is greater than without sympathetic stimulation. The increased [Ca2+]i is further amplified by Ca2+-induced Ca2+-release (CICR) from the sarcoplasmic reticulum ryanodine receptor Ca2+ release channels, leading to strengthened contraction. In CICR in the heart, both cyclic ADP-ribose (cADP-ribose) and Ca2+ cooperatively activate type-II ryanodine receptors to release Ca2+. However, no information on the concentration of cADP-ribose after β-adrenoceptor stimulation has yet been reported (Figure 2).
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References
Hashii, M., Minabe, Y. and Higashida, H., 2000, Cyclic ADP-ribose potentiates Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108–15 neuronal cells. Biochem. J. 345, 207–215.
Higashida, H., Egorova, A., Higashida, C., Zhong, Z.-G., Yokoyama, S., Noda, M. and Zhang, J.-S., 1999, Sympathetic potentiation of cyclic ADP-ribose formation in rat cardiac myocytes. J. Biol. Chem. 274, 33348–33354.
Higashida, H., Hashii, M., Yokoyama, S., Hoshi, N., Asai, K. and Kato, T., 2001, Cyclic ADP-ribose as a potential second messenger for neuronal Ca2+ signaling. J. Neurochem. 76, 321–331.
Higashida, H., Yokoyama, S., Hashii, M., Taketo, M., Higashida, M., Takayasu, T., Ohshima, T., Takasawa S., Okamoto, H. and Noda, M., 1997, Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108–15 neuronal cell membranes. J. Biol. Chem. 272, 31272–31277.
Higashida, H., Zhang, J., Hashii, M., Shintaku, M., Higashida, C., Takeda, Y., 2000, Angiotensin II stimulates cyclic ADP-ribose formation in neonatal rat cardiac myocytes. Biochem. J. 352,197–202.
Hotta, T., Asai, K., Fujita, K., Kato, T. and Higashida, H., 2000, Membrane-bound form of ADP-ribosyl cyclase in rat cortical astrocytes in culture. J. Neurochem. 74, 669–675.
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© 2002 Springer Science+Business Media New York
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Higashida, H. et al. (2002). Sympathetic Potentiation of Cyclic ADP-Ribose Formation in Rat Cardiac Myocytes. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_14
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DOI: https://doi.org/10.1007/978-1-4757-3538-3_14
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