Molecular Biology of Conformational Diseases
An important family of diseases is characterized by the presence of a disease-specific protein that accumulates as “amyloid” fibers and thereby becomes toxic to the cell. Although the protein has the authentic primary sequence (except in familial cases), it adopts a non-native conformation which resists proteolysis, allowing the protein to accumulate and form fibers. Non-familial amyloid conditions are clearly epigenetic.
KeywordsMisfolded Protein Prion Disease Synonymous Codon Translation Rate Nascent Protein
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