Evaluation of Sympathetic Nerve Function in Patients with Heart Failure by MIBG Myocardial Scintigraphy

  • Junichi Yamazaki
  • Shohei Yamashina
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Patients with heart failure show signs of sympathetic dysfunction, including an elevation in blood norepinephrine levels, and down-regulation of beta-receptors. The reported changes in these patients include a reduction in the number of sympathetic nerves, and a decrease in myocardial norepinephrine (NE) content (1). 123I-Metaiodobenzylguanidine (MIBG) has been developed for imaging of the kinetics of NE in vivo. MIBG uptake is reduced, and washout is increased in the failing heart due to increased turnover or spillover of NE plasma, poor retention, and NE re-uptake disorder at sympathetic nerve endings (2, 3). We performed this study to determine which parameter of 123I-MIBG image is an accurate predictor of the response to beta-blocker therapy, and to evaluate differences in therapeutic effects among various beta-blockers in patients with dilated cardiomyopathy (DCM).


Left Ventricular Ejection Fraction Dilate Cardiomyopathy Sympathetic Nerve Washout Rate MIBG Uptake 
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  1. 1.
    Rector TS, Olivari MT, Levine TB, et al, Predicting survival for an individual with congestive heart failure using the plasma norepinephrine concentration, Am. Heart J, 113, 148–152 (1987).CrossRefGoogle Scholar
  2. 2.
    Yamazaki J, Muto H, Ishiguro K, et al, Quantitative scintigraphic analysis of 123I-MIBG by polar map in patients with dilated cardiomyopathy, Nucl. Med. Commun, 18, 219–229 (1997).PubMedCrossRefGoogle Scholar
  3. 3.
    Yamazaki J, H Muto, T Kabano, et al, Evaluation of ß-blocker therapy in patients with dilated cardiomyopathy —Clinical meaning of iodine 123- MIBG metaiodobenzylguanidine myocardial single- photon emission computed tomography, Am. Heart J, 141, 645–652 (2001).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Junichi Yamazaki
  • Shohei Yamashina
    • 1
  1. 1.The First Department of Internal MedicineToho University School of MedicineOhta-ku, TokyoJapan

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