Neuroprotective Actions of Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate in Models of Parkinson’s Disease: Gene Targets

  • Silvia Mandel
  • Yona Levites
  • Orly Weinreb
  • Moussa B. H. Youdim
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Biochemical evidence points to central roles for oxidative stress (OS) and inflammation in neuronal death in both idiopathic and animal models of Parkinson’s disease (PD). Reports from our laboratory, as supported by others, point to the presence of ongoing OS and inflammatory processes occurring selectively in the substantia nigra pars compacta (SNPC) of parkinsonian brains and in animal models of PD.1–4 Therefore, drugs that exhibit free radical-scavenging and iron chelating properties, may serve as potential candidates for the treatment of PD.


Neuronal Cell Culture Cell Cycle Pathway Parkinsonian Brain EGCG Concentration Nuclear Factor kappaB Activity 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Silvia Mandel
  • Yona Levites
  • Orly Weinreb
  • Moussa B. H. Youdim
    • 1
  1. 1.Department of Pharmacology, Technion- Faculty of MedicineEve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases ResearchHaifaIsrael

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