ß-Carbolines and N-Methylation Underlying Parkinson’s Disease
The discovery of MPTP leads to the hypothesis that Parkinson’s disease (PD) is may be initiated or precipitated by endogenous toxins by the mechanism similar to that of MPTP in genetically-predisposed individuals. The higher cerebrospinal fluid (CSF) levels of N-methylated azaheterocyclic amines, such as ß-carbolines (ßCs) and tetrahydroisoquinoline, have been found in PD patients. Thus, there is a hypothesis to influence the pathogenesis of PD, that is, the excess enzyme activity to activate neurotoxins, such as N-methyltransferase, might be higher in PD patients (Matsubara et al., 1998a).
KeywordsTyrosine Hydroxylase Lumbar Cerebrospinal Fluid Endogenous Toxin Aldehyde Oxidase Activity Endogenous Neurotoxin
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