Dopaminergic Impairment Is Related to Cortical Dysfunction in Parkinson’s Disease

A PET study
  • Kengo Ito
  • Yutaka Arahata
  • Atsuko Nagano-Saito
  • Yuji Abe
  • Takashi Kato
  • Akinori Nakamura
  • Yasuhiro Kawasumi
  • Kentaro Hatano
  • Takako Yamada
  • Teruhiko Kachi
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

There may be involvement of extrastriatal dopamine terminals to varying extents in different subgroups of idiopathic Parkinson’s disease (PD). Accurate detection of changes in extrastriatal areas is unreliable using conventional ROI analysis. As a consequence the ROI approach is not really suited for use as an exploratory technique with 6-[18F]fluoro-L dopa (FDOPA) PET. For that reason we developed the spatial normalization for FDOPA influx (Ki) images to assess the extrastriatal uptake of FDOPA in the normal and PD.1–3.

Keywords

Ventral Tegmental Area Caudate Nucleus Statistical Parametric Mapping Cortical Dysfunction Mesolimbic Dopaminergic System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kengo Ito
    • 1
  • Yutaka Arahata
    • 1
  • Atsuko Nagano-Saito
    • 1
  • Yuji Abe
    • 1
  • Takashi Kato
    • 1
  • Akinori Nakamura
    • 1
  • Yasuhiro Kawasumi
    • 1
  • Kentaro Hatano
    • 1
  • Takako Yamada
    • 2
  • Teruhiko Kachi
    • 2
  1. 1.National Institute for Longevity SciencesObuJapan
  2. 2.Chubu National HospitalObuJapan

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