Dopaminergic Impairment Is Related to Cortical Dysfunction in Parkinson’s Disease
There may be involvement of extrastriatal dopamine terminals to varying extents in different subgroups of idiopathic Parkinson’s disease (PD). Accurate detection of changes in extrastriatal areas is unreliable using conventional ROI analysis. As a consequence the ROI approach is not really suited for use as an exploratory technique with 6-[18F]fluoro-L dopa (FDOPA) PET. For that reason we developed the spatial normalization for FDOPA influx (Ki) images to assess the extrastriatal uptake of FDOPA in the normal and PD.1–3.
KeywordsVentral Tegmental Area Caudate Nucleus Statistical Parametric Mapping Cortical Dysfunction Mesolimbic Dopaminergic System
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