Platelet Monoamine Oxidase, Transcription Factor AP-2 and Personality — A Functional Triangle?

  • Lars Oreland
  • Mattias Damberg
  • Håkan Garpenstrand
  • Jaanus Harro
  • Jarmila Hallman
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Almost thirty years ago it was discovered that low activity of the enzyme monoamine oxidase (MAO; E.C. in blood platelets, which is to about 75% genetically regulated,1 is strongly linked to personality traits such as impulsiveness and sensation seeking.2; see 3 Mountaineers4 and pathological gamblers5 have lower activity of the enzyme than controls, an observation also made in type 2 alcoholics (males with a heavy genetic disposition) and individuals prone to commit violent crimes (see 3). It has also been shown that new-born babies with low platelet MAO are crying more and are more difficult to console than those with medium activity.6 Furthermore, platelet MAO activity in free-living monkeys has been shown to be linked to behaviour as well as to voluntary alcohol intake.7, 8


Binge Eating Pathological Gamblers5 Amine Oxidase Activity Enzyme Monoamine Oxidase Platelet Monoamine Oxidase 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Lars Oreland
  • Mattias Damberg
  • Håkan Garpenstrand
  • Jaanus Harro
  • Jarmila Hallman
    • 1
    • 2
  1. 1.Dept. of NeuroscienceUppsala UniversityUppsalaSweden
  2. 2.Dept. of PsychologyTartu UniversityTartuEstonia

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