Tetrahydrobiopterin Differentially Regulates the Biosynthesis of Catecholamines and Serotonin
Catecholamines, e.g., dopamine (DA), norepinephrine, and epinephrine, and serotonin (5HT) are important neurotransmitters in the brain. They are well known to be involved in the regulation of various aspects of brain function, including emotion, motivation, addiction, aggressiveness, and involuntary movement. Alteration in the metabolism of these monoamines leads to abnormalities in behavior and neuropsychiatric states.
KeywordsTyrosine Hydroxylase Nerve Terminal Serotonergic Neuron Homozygous Mutant Mouse Sepiapterin Reductase
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