Dopaminergic Hyperactivity in Striatum in Schizophrenia: A Failure of Cortical Glutamatergic Control?

  • Lawrence S. Kegeles
  • Marc Laruelle
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


The classical dopamine hypothesis of schizophrenia proposes that positive symptoms of the disorder are a result of hyperactivity of dopamine transmission.1 This hypothesis has received new support from brain imaging studies that have shown an exaggerated response to acute amphetamine challenge in untreated patients with schizophrenia compared with healthy subjects using dopamine D2 receptor SPECT (single photon emission computed tomography) or PET (positron emission tomography).2–4


Positron Emission Tomography Dopamine Release Positron Emission Tomography Study Dopamine Transmission NMDA Receptor Blockade 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Lawrence S. Kegeles
  • Marc Laruelle
    • 1
  1. 1.Departments of Psychiatry and RadiologyColumbia UniversityNew YorkUSA

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