Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression
Dopamine β-hydroxylase (Dβ H) catalyzes the conversion of dopamine to norepinephrine. It is localized within neurosecretory vesicles of noradrenergic and adrenergic neurons and neurosecretory cells, where it is present in both soluble and membrane bound fractions. DβH enzyme activity can be measured in plasma or serum. Enzyme activity and levels of DβH protein in these body fluids are strongly correlated and essentially reflect the same biochemical trait. DβH levels are strongly influenced by genetic inheritance (Weinshilboum, 1978) and the structural locus encoding DβH protein, Dβ H, is the major locus controlling the trait (Zabetian et al., 2001).
KeywordsDepressed Patient African American Unipolar Depression Psychotic Feature Unipolar Major Depression
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