Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression

New implications for an old biomarker
  • Joseph F. Cubells
  • Cyrus P. Zabetian
  • George M. Anderson
  • Lawrence H. Price
  • Barnett S. Meyers
  • Robert T. Malison
  • J. Craig Nelson
  • Toshiharu Nagatsu
  • Hiroshi Ichinose
  • Joel Gelernter
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Dopamine β-hydroxylase (Dβ H) catalyzes the conversion of dopamine to norepinephrine. It is localized within neurosecretory vesicles of noradrenergic and adrenergic neurons and neurosecretory cells, where it is present in both soluble and membrane bound fractions. DβH enzyme activity can be measured in plasma or serum. Enzyme activity and levels of DβH protein in these body fluids are strongly correlated and essentially reflect the same biochemical trait. DβH levels are strongly influenced by genetic inheritance (Weinshilboum, 1978) and the structural locus encoding DβH protein, Dβ H, is the major locus controlling the trait (Zabetian et al., 2001).

Keywords

Depressed Patient African American Unipolar Depression Psychotic Feature Unipolar Major Depression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Joseph F. Cubells
    • 1
  • Cyrus P. Zabetian
    • 1
  • George M. Anderson
    • 1
  • Lawrence H. Price
    • 2
  • Barnett S. Meyers
    • 3
  • Robert T. Malison
    • 1
  • J. Craig Nelson
    • 1
  • Toshiharu Nagatsu
    • 4
  • Hiroshi Ichinose
    • 4
  • Joel Gelernter
    • 1
  1. 1.Yale University School of Medicine and VA ConnecticutWest HavenUSA
  2. 2.Brown University School of MedicineProvidenceUSA
  3. 3.Cornell University Medical CollegeWhite PlainsUSA
  4. 4.Fujita Health UniversityToyoakeJapan

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