Radioimmunodetection of Cancer

  • E. Edmund Kim


Radiolabeled monoclonal antibodies have gained widespread acceptance as relatively receptor-specific radiopharmaceuticals for clinical applications. Over the past decade, several clinical trials have demonstrated the ability of radiolabeled antibodies to localize certain cancers with sensitivities and specificities comparable to and, in some instances, superior to conventional diagnostic modalities. The U.S. Food and Drug Administration (FDA) has approved four radiolabeled monoclonal antibody conjugates for human use: satumormab pendetide (OncoScint; Cytogen) for colorectal and ovarian cancer; arcitumomab (CEA-Scan; Immunomedics) for colorectal cancer; capromab pendetide (ProstaScint; Cytogen) for prostate carcinoma, and nofetumomab merpentan (Verluma; DuPont Radiopharrmaceuticals) for small-cell lung carcinoma.


Prostate Cancer Ovarian Cancer Hepatic Metastasis Germ Cell Tumor Medullary Thyroid Cancer 
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© Springer Science+Business Media New York 2001

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  • E. Edmund Kim

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