Skip to main content

Transplantation in Elderly Patients

  • Chapter
  • 309 Accesses

Abstract

As the United States population ages and as results of transplantation improve, there are increasing numbers of older patients who avail themselves of transplantation. As a consequence, the percentage of older waiting list individuals has been increasing.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Agodoa LY, Eggers PW. Renal replacement therapy in the United States: data from the United States renal data system. Am J Kidney Dis 1995;25:119–133.

    Article  PubMed  CAS  Google Scholar 

  2. Inglehart G. The American health care system: the end stage renal disease program. N Engl J Med 1993;328:366.

    Article  Google Scholar 

  3. Bonal J, Cleries M, Vela E. Renal Registry Committee. Transplantation versus haemodialysis in elderly patients: Renal Registry Committee. Nephrol Dial Transplant 1997;12: 261–264.

    Article  PubMed  CAS  Google Scholar 

  4. Schaubel D, Desmeules M, Mao Y, et al. Survival experience among elderly end-stage renal disease patients. A controlled comparison of transplantation and dialysis. Transplantation 1995;60:1389–1394.

    Article  PubMed  CAS  Google Scholar 

  5. Nyberg G, Nilsson B, Hallste G, et al. Renal transplantation in elderly patients: survival and complications. Transplant Proc 1993;25:1062–1063.

    PubMed  CAS  Google Scholar 

  6. Albrechtsen D, Leivestad T, Sodal G, et al. Kidney transplantation in patients older than 70 years of age. Transplant Proc 1995;27:986–988.

    PubMed  CAS  Google Scholar 

  7. Eggers P. Effect of transplantation on the Medicare end-stage renal disease program. N Engl J Med 1988;1:223.

    Article  Google Scholar 

  8. Wedel N, Brynger H, Blohme I. Kidney transplantation in patients 60 years and older. Scand J Urol Nephrol 1980; 54(suppl):106.

    CAS  Google Scholar 

  9. Kock B, Luhlback B, Ahonen J, et al. Kidney transplantation in patients over 60 years of age. Scand J Urol Nephrol 1980; 54(suppl)7:103.

    CAS  Google Scholar 

  10. Ost L, Groth C, Lindholm B, et al. Cadaveric renal transplantation in patients of 60 years and above. Transplantation 1980;30:339–340.

    Article  PubMed  CAS  Google Scholar 

  11. Hunsicker L. Impact of cyclosporine on cadaveric renal transplantation: a summary statement. Am J Kidney Dis 1985;6:335.

    Google Scholar 

  12. Pirsch JD, Stratta RJ, Armbrust MJ, et al. Cadaveric renal transplantation with cyclosporine in patients more than 60 years of age. Transplantation 1989;47:259–261.

    Article  PubMed  CAS  Google Scholar 

  13. Sommer B, Ferguson R, Davin T, et al. Renal transplantation in patients over 50 years of age. Transplant Proc 1981;13: 33–35.

    PubMed  CAS  Google Scholar 

  14. Lundgren G, Fehrman I, Gunnarson B, et al. Cadaveric renal transplantation in patients over 55 years of age with special emphasis on immunosuppressive therapy. Transplant Proc 1982;14:601–604.

    PubMed  CAS  Google Scholar 

  15. Vollmer W, Wahl P, Blagg C. Survival with dialysis and transplantation in patients with end-stage renal disease. N Engl J Med 1983;308:1553–1558.

    Article  PubMed  CAS  Google Scholar 

  16. Taube D, Winder E, Ogg C, et al. Successful treatment of middle aged and elderly patients with end-stage renal failure. Br Med J 1983;286:2018–2020.

    Article  CAS  Google Scholar 

  17. Hutchinson T, Thomas D, Lemieux J, Harvey C. Prognostically controlled comparison of dialysis and renal transplantation. Kidney Int 1984;26:44–51.

    Article  PubMed  CAS  Google Scholar 

  18. Garcia-Garcia G, Deddens J, D’Achiardi-Rey R, et al. Results of treatment in patients with end stage renal disease: a multi-variate analysis of risk factors and survival in 341 successive patients. Am J Kidney Dis 1984;5:10–18.

    Google Scholar 

  19. Burton P, Walls J. Selection-adjusted comparison of life-expectancy of patients on continuous ambulatory peritoneal dialysis, haemodialysis, and renal transplantation. Lancet 1987;1:1115–1119.

    Article  PubMed  CAS  Google Scholar 

  20. Lindner A, Charre B, Sherrard D, Scribner B. Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med 1974;290:697–701.

    Article  PubMed  CAS  Google Scholar 

  21. Tesi RJ, Elkhammas EA, Davies EA, et al. Renal transplantation in older people. Lancet 1994;343:461–464.

    Article  PubMed  CAS  Google Scholar 

  22. Benedetti E, Matas AJ, Hakim N, et al. Renal transplantation for patients 60 years of older: a single-institution experience. Ann Surg 1994;220:445–458.

    Article  PubMed  CAS  Google Scholar 

  23. Abouna GM, Kumar MS, Curfman K, Phillips K. Kidney transplantation in patients older than 60 years of age—is it worth it? Transplant Proc 1995;27:2567–2568.

    PubMed  CAS  Google Scholar 

  24. Berthoux FC, Jones EH, Mehls O, Valderrabano F. Transplantation report. 1. Renal transplantation in recipients aged 60 years or older at time of grafting: the EDTA-ERA Registry, European Dialysis and Transplant Association-European Renal Association. Nephrol Dial Transplant 1996;11(suppl 1):37–40.

    Article  PubMed  Google Scholar 

  25. Hestin D, Frimat L, Hubert J, et al. Renal transplantation in patients over sixty years of age. Clin Nephrol 1994;42: 232–236.

    PubMed  CAS  Google Scholar 

  26. Cantarovich D, Baatard R, Baranger T, et al. Cadaveric renal transplantation after 60 years of age: a single center experience. Transpl Int 1994;7:33–38.

    PubMed  CAS  Google Scholar 

  27. Sharma AK, Brown M, Connolly J, et al. Analysis of factors affecting the outcome of renal transplantation in older people. Transplant Proc 1997;29:261.

    Article  PubMed  CAS  Google Scholar 

  28. Nyberg G, Nilsson B, Norden G, Karlberg I. Outcome of renal transplantation in patients over the age of 60: a case-control study Nephrol Dial Transplant 1995;10:91–94.

    PubMed  CAS  Google Scholar 

  29. Phillips AO, Bewick M, Snowden SA, et al. The influence of recipient and donor age on the outcome of renal transplantation. Clin Nephrol 1993;40:352–354.

    PubMed  CAS  Google Scholar 

  30. Andreu J, de la Torre M, Oppenheimer F, et al. Renal transplantation in elderly recipients. Transplant Proc 1992; 24:120–121.

    PubMed  CAS  Google Scholar 

  31. Mourad G, Cristol JP, Vela C, et al. Cadaveric renal transplantation in patients 60 years of age and older: experience with 58 patients in a single centre. Nephrol Dial Transplant 1995;10(suppl 6):105–107.

    Article  PubMed  Google Scholar 

  32. Hirata M, Cho Y, Cecka J, Terasaki P. Patient death after renal transplantation: an analysis of its role in graft outcome. Transplantation 1996;61:1479–1483.

    Article  PubMed  CAS  Google Scholar 

  33. West M, Sutherland D, Matas A. Kidney transplant recipients who die with functioning grafts. Transplantation 1996; 62:1029–1030.

    PubMed  CAS  Google Scholar 

  34. Matas A, Gillingham K, Sutherland D. Half-life and risk factors for kidney transplant outcome: importance of death with function. Transplantation 1993;55:757–761.

    Article  PubMed  CAS  Google Scholar 

  35. Marwick T, Steinmuller D, Underwood D, et al. Ineffectiveness of dipyridamole SPECT thallium imaging as a screening technique for coronary artery disease in patients with end-stage renal failure. Transplantation 1990;49:100–103.

    Article  PubMed  CAS  Google Scholar 

  36. Boudreau R, Strony J, duCret R, et al. Perfusion thallium imaging of type I diabetes patients with end stage renal disease: comparison of oral and intravenous dipyridamole administration. Radiology 1990;175:103–105.

    PubMed  CAS  Google Scholar 

  37. Brown JH, Vites NP, Testa HJ, et al. Value of thallium myocardial imaging in the prediction of future cardiovascular events in patients with end-stage renal failure. Nephrol Dial Transplant 1993;8:433–437.

    PubMed  CAS  Google Scholar 

  38. Reis G, Marcovitz PA, Leichtman AB, et al. Usefulness of dobutamine stress echocardiography in detecting coronary artery disease in end-stage renal disease. Am J Cardiol 1995; 75:707–710.

    Article  PubMed  CAS  Google Scholar 

  39. Pirsch JD, Kalayoglu M, Am DA, et al. Orthotopic liver transplantation in patients 60 years of age and older. Transplant Proc 1991;51:431–433.

    Article  CAS  Google Scholar 

  40. Stieber AC, Gordon RD, Todo S, et al. Liver transplantation in patients over sixty years of age. Transplantation 1991; 51:271–273.

    Article  PubMed  CAS  Google Scholar 

  41. United Kingdom Transplant Support Service Authority. Annual Report, 1993.

    Google Scholar 

  42. Bromley PN, Hilmi I, Tan KC, et al. Orthotopic liver transplantation in patients over 60 years old. Transplantation 1994;58:800–803.

    PubMed  CAS  Google Scholar 

  43. Kilpe VE, Krakauer H, Wren RE. An analysis of liver transplant experience from 37 transplant centers as reported to Medicare. Transplantation 1993;56:554–561.

    Article  PubMed  CAS  Google Scholar 

  44. Hosenpud JD, Bennett LE, Keck BM, et al. The Registry of the International Society for Heart and Lung Transplantation: fourteenth official report—1997. J Heart Lung Transplant 1997;16:691–712.

    PubMed  CAS  Google Scholar 

  45. Fabbri A, Sharpies LD, Mullins P, et al. Heart transplantation in patients over 54 years of age with triple-drug therapy immunosuppression. J Heart Lung Transplant 1992;11:929–932.

    PubMed  CAS  Google Scholar 

  46. Kaye M. The Registry of the International Society for Heart and Lung Transplantation: ninth official report— 1992. J Heart Lung Transplant 1992;11:599–606.

    Google Scholar 

  47. O’Connell J, Gunnar R, Evans R, et al. 24th Bethesda conference: task force 1: organization of heart transplantation in the U.S. J Am Coll Cardiol 1993;22:8–14.

    Article  PubMed  Google Scholar 

  48. Rickenbacher PR, Lewis NP, Valantine HA, et al. Heart transplantation in patients over 54 years of age: mortality, morbidity and quality of life. Eur Heart J 1997;18:870–878.

    PubMed  CAS  Google Scholar 

  49. Blanche C, Takkenberg JJ, Nessim S, et al. Heart transplantation in patients 65 years of age and older: a comparative analysis of 40 patients. Ann Thorac Surg 1996;62:1442–1446.

    Article  PubMed  CAS  Google Scholar 

  50. Everett JE, Djalilian AR, Kubo SH, et al. Heart transplantation for patients over age 60. Clin Transplant 1996;10:478–481.

    PubMed  CAS  Google Scholar 

  51. Bull DA, Karwande SV, Hawkins JA, et al. Long-term results of cardiac transplantation in patients older than sixty years: UTAH cardiac transplant program. J Thorac Cardiovasc Surg 1996;111:423–427.

    Article  PubMed  CAS  Google Scholar 

  52. Gheissari A, Yokoyama T, Hendel J, Fuentes J. Effect of advanced age on short- and long-term outcome of heart transplantation. Transplant Proc 1995;27:2628–2632.

    PubMed  CAS  Google Scholar 

  53. Robin J, Ninet J, Tronc F, et al. Long-term results of heart transplantation deteriorate more rapidly in patients over 60 years of age. Eur J Cardiothorac Surg 1996;10:259–263.

    Article  PubMed  CAS  Google Scholar 

  54. Heroux AL, Costanzo-Nordin MR, Je OS, et al. Heart transplantation as a treatment option for end-stage heart disease in patients older than 65 years of age. J Heart Lung Transplant 1993;12:573–578.

    PubMed  CAS  Google Scholar 

  55. Aravot DJ, Banner NR, Khaghani A, et al. Cardiac transplantation in the seventh decade of life. Am J Cardiol 1989;63:90–93.

    Article  PubMed  CAS  Google Scholar 

  56. Frazier OH, Macris MP, Duncan JM, et al. Cardiac transplantation in patients over 60 years of age. Ann Thorac Surg 1988;45:129–132.

    Article  PubMed  CAS  Google Scholar 

  57. Ott GY, Norman DJ, Hosenpud JD, et al. Heart transplantation in patients with previous cardiac operations: excellent clinical results. J Thorac Cardiovasc Surg 1994;107:203–209.

    PubMed  CAS  Google Scholar 

  58. Carrel T, Neth J, Mohacsi P, et al. Perioperative risk and long-term results of heart transplantation after previous cardiac operations. Ann Thorac Surg 1997;63:1133–1137.

    Article  PubMed  CAS  Google Scholar 

  59. Billingham ME, Cary NR, Hammond ME, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group, The International Society for Heart Transplantation. J Heart Transplant 1990;9:587–593.

    PubMed  CAS  Google Scholar 

  60. Kobashigawa JA, Kirklin JK, Naftel DC, et al. Pretransplantation risk factors for acute rejection after heart transplantation: a multiinstitutional study: the Transplant Cardiologists Research Database Group. J Heart Lung Transplant 1993;12:355–366.

    PubMed  CAS  Google Scholar 

  61. Renlund DG, Gilbert EM, Gay WA Jr, et al. Age-associated decline in cardiac allograft rejection. Am J Med 1987;83: 391–398.

    Article  PubMed  CAS  Google Scholar 

  62. Miller LW, Vitale-Noedel N, Pennington G, et al. Heart transplantation in patients over age fifty-five years. J Heart Transplant 1988;7:254–257.

    PubMed  CAS  Google Scholar 

  63. Olivari MT, Antolick A, Kaye MP, et al. Heart transplantation in elderly patients. J Heart Transplant 1988;7:258–264.

    PubMed  CAS  Google Scholar 

  64. Snell GI, De Hoyos A, Winton T, Maurer JR. Lung transplantation in patients over the age of 50. Transplantation 1993;55:562–566.

    Article  PubMed  CAS  Google Scholar 

  65. Morrison DL, Maurer JR, Grossman RR Preoperative assessment for lung transplantation. Clin Chest Med 1990;11:207–215.

    PubMed  CAS  Google Scholar 

  66. Berry GJ, Brunt EM, Chamberlain EM, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Lung Rejection Study Group, The International Society for Heart Transplantation. J Heart Transplant 1990;9:593–601.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media New York

About this chapter

Cite this chapter

Feng, S., Tomlanovich, S.L., Keith, F., Ascher, N.L. (2001). Transplantation in Elderly Patients. In: Rosenthal, R.A., Zenilman, M.E., Katlic, M.R. (eds) Principles and Practice of Geriatric Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3432-4_68

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-3432-4_68

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-3434-8

  • Online ISBN: 978-1-4757-3432-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics