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Effects of Aging on Immune Function

  • Chapter
Principles and Practice of Geriatric Surgery

Abstract

At first glance, a review of immune system changes with age may seem out of place in a surgical textbook. After stopping to consider for a few moments, however, it begins to make sense that such a topic be included. The traditional approach to describing immune function focuses on the role of cellular components in protection against infection and cancer and the diseases that result from hyper- or hypoactivity of these components. Proper function of the immune system is imperative if the body is to heal and protect itself properly, not only after microbial invasion or neoplastic transformation but after physical invasion, such as trauma and surgery. A well-functioning immune system helps ensure optimum wound healing and minimizes the risk of infection. As adults over age 85 years continue to be the fastest growing segment of the population, an increasingly larger proportion of patients taken to surgery will be in the geriatric age range. Age-related changes in immune function will assume greater significance during management of these patients surgically and in overall clinical practice.

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Authors
  1. Edith A. Burns
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  2. James S. Goodwin
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Editor information

Editors and Affiliations

  1. Department of Surgery, Yale University School of Medicine, New Haven, CT, 06520, USA

    Ronnie A. Rosenthal MD (Associate Professor, Chief, Surgical Service) (Associate Professor, Chief, Surgical Service)

  2. Department of Veterans Affairs, VA Connecticut Healthcare System, West Haven, 06516, CT, USA

    Ronnie A. Rosenthal MD (Associate Professor, Chief, Surgical Service) (Associate Professor, Chief, Surgical Service)

  3. Department of Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, 10461, NY, USA

    Michael E. Zenilman MD (Associate Professor and Vice-Chairman, Chief of Surgery) (Associate Professor and Vice-Chairman, Chief of Surgery)

  4. Jack D. Weiler Hospital of the Albert Einstein College of Medicine, Bronx, 10461, NY, USA

    Michael E. Zenilman MD (Associate Professor and Vice-Chairman, Chief of Surgery) (Associate Professor and Vice-Chairman, Chief of Surgery)

  5. Wyoming Valley Surgical Associates, Kingston, 18704, PA, USA

    Mark R. Katlic M.D. (Chief of Thoracic Surgery) (Chief of Thoracic Surgery)

  6. Wyoming Valley Healthcare System, Wilkes-Barre, 18702, PA, USA

    Mark R. Katlic M.D. (Chief of Thoracic Surgery) (Chief of Thoracic Surgery)

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© 2001 Springer Science+Business Media New York

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Burns, E.A., Goodwin, J.S. (2001). Effects of Aging on Immune Function. In: Rosenthal, R.A., Zenilman, M.E., Katlic, M.R. (eds) Principles and Practice of Geriatric Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3432-4_4

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  • DOI: https://doi.org/10.1007/978-1-4757-3432-4_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-3434-8

  • Online ISBN: 978-1-4757-3432-4

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