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Pathophysiology and Treatment of Benign Diseases of the Stomach and Duodenum

  • Chapter
Principles and Practice of Geriatric Surgery

Abstract

Evaluation of the elderly patient with complaints of upper abdominal discomfort is often difficult and frustrating for both the patient and the physician. A multitude of processes may have similar presentations, including cardiac, respiratory, renal, and gastrointestinal processes. A malignant process must also be considered more frequently in the elderly patient than in the young or middle-aged patient. In the elderly patient, the presentation of a true pathologic process is often obscured by functional disorders of the upper digestive tract, which accounts for nearly 30% of all office visits.1 Also confounding the evaluation of the elderly patient are the multiple co-morbid disease processes frequently encountered and the polypharmacy treatment regimens administered by different specialists.

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References

  1. Levitan R. GI problems in the elderly. Part II. Prevalent disease and disorders. Geriatrics 1989;44:80–86.

    PubMed  CAS  Google Scholar 

  2. Bird T, Hall MR, Schade RO. Gastric histology and its relation to anemia in the elderly. Gerontology 1977;23:309–321.

    Article  PubMed  CAS  Google Scholar 

  3. Palmer E. Gastritis: a reevaluation. Medicine 1954;35: 199–210.

    Article  Google Scholar 

  4. Khanna PB, Davies I, Faragher EB. Age-related changes in the stomach of laboratory mouse: a quantitative morphological study. Age Ageing 1988;17:257–264.

    Article  PubMed  CAS  Google Scholar 

  5. Majumdar APN, Johnson LR. Gastric mucosal cell proliferation during development in rats and effect of penta-gastrin. Am J Physiol 1982;242:G135–G139.

    PubMed  CAS  Google Scholar 

  6. Majumdar APN, Edgerton EA, Dayal Y, et al. Gastrin: levels and trophic action during advancing age. Am J Physiol 1988;254:G538–G542.

    PubMed  CAS  Google Scholar 

  7. Majumdar APN, Jasti S, Hatfiels JS, et al. Morphological and biochemical changes in gastric mucosa of aging rats. Dig Dis Sci 1990;35:1364–1370.

    Article  PubMed  CAS  Google Scholar 

  8. Khaliil T, Fujimura SP, Townsend CM Jr, et al. Effect of aging on gastric acid secretion, serum gastrin, and antral gastrin content in rats. Dig Dis Sci 1988;33:1544–1548.

    Article  Google Scholar 

  9. Kogire M, Ishizuka J, Parekh D, et al. Effects of aging on gastrin and somatostatin secretion from isolated perfused rat stomach. Dig Dis Sci 1993;38:303–308.

    Article  PubMed  CAS  Google Scholar 

  10. Lee M, Feldman M. Age-related reductions in gastric mucosal prostaglandin levels increase susceptibility to aspirin-induced injury in rats. Gastroenterology 1994;107: 1746–1750.

    Article  PubMed  CAS  Google Scholar 

  11. Blackman AH, Lambert DL, Thayer WR, et al. Computed normal values for peak acid output based on age, sex, and body weight. Am J Dig Dis 1970;15:783–789.

    Article  PubMed  CAS  Google Scholar 

  12. Cleator IGM, Stoller JL, Nunn PN, et al. Discriminant analysis of data in ulcer and nonulcer populations. Dig Dis Sci 1973;18:301–310.

    Article  CAS  Google Scholar 

  13. Goldschmiedt M, Barnett CC, Schwarz BE, et al. Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. Gastroenterology 1991; 101:977–990.

    PubMed  CAS  Google Scholar 

  14. Cryer B, Redfern JS, Goldschmiedt M, et al. Effects of aging on gastric and duodenal mucosal prostaglandin concentrations in humans. Gastroenterology 1992;102:1118–1123.

    PubMed  CAS  Google Scholar 

  15. Kekki M, Sipponen P, Siurala M. Age behavior of gastric acid secretion in males and females with a normal antral and body mucosa. Scand J Gastroenterol 1983;18:1009–1016.

    Article  PubMed  CAS  Google Scholar 

  16. Kekki M, Samloff IM, Ihamaki T, Varis K, Siurala M. Age-and sex-related behavior of gastric acid secretion at the population level. Scand J Gastroenterol 1982;17:737–743.

    Article  PubMed  CAS  Google Scholar 

  17. Katelaris PH. Effects of age, Helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men. Gut 1993;34:1032–1037.

    Article  PubMed  CAS  Google Scholar 

  18. Husebye E, Skar V, Hoverstad T, Melby K. Fasting hypochlorhydria with gram positive gastric flora is highly prevalent in healthy old people. Gut 1992;33:1331–1337.

    Article  PubMed  CAS  Google Scholar 

  19. Cryer B, Lee E, Feldman M. Factors influencing gastro-duodenal mucosal prostaglandin concentrations: roles of smoking and aging. Ann Intern Med 1992;116:636–640.

    Article  PubMed  CAS  Google Scholar 

  20. Kupfer RM, Heppell M, Haggith JW, et al. Gastric emptying and small-bowel transit rate in the elderly. J Am Geriatr Scoc 1985;33:340–343.

    CAS  Google Scholar 

  21. Madsen JL. Effect of gender, age, and body mass index on gastrointestinal transit times. Dig Dis Sci 1992;37:1548–1553.

    Article  PubMed  CAS  Google Scholar 

  22. Horowitz M, Maddern GJ, Chatterton BE, et al. Changes in gastric emptying rates with age. Clin Sci 1984;67:213–218.

    PubMed  CAS  Google Scholar 

  23. Moore JG, Tweedy C, Christian PE, et al. Effect of age on gastric emptying of liquid-solid meals in man. Dig Dis Sci 1983;28:340–344.

    Article  PubMed  CAS  Google Scholar 

  24. Kao CH, Lai TL, Wang SJ, et al. Influence of age on gastric emptying in healthy Chinese. Clin Nucl Med 1994;19: 401–404.

    Article  PubMed  CAS  Google Scholar 

  25. Wedmann B, Schmidt G, Wegener M, et al. Effects of age and gender on fat-induced gallbladder contraction and gastric emptying of a caloric liquid meal: a sonographic study. Am J Gastroenterol 1991;86:1765–1770.

    PubMed  CAS  Google Scholar 

  26. Kurata, JH. Ulcer epidemiology: an overview and proposed research framework. Gastroenterology 1989;96: 569–580.

    PubMed  CAS  Google Scholar 

  27. Kurata JH, Haile BM. Epidemiology of peptic ulcer disease. Clin Gastroenterol 1984;13:289–307.

    PubMed  CAS  Google Scholar 

  28. Elashoff J, Grossman MI. Trends in hospital admissions and death rates for peptic ulcers in the United States from 1970 to 1978. Gastroenterology 1980;20:200–205.

    Google Scholar 

  29. Kurata JH, Corboy ED. Current peptic ulcer trends: an epidemiological profile. J Clin Gastroenterol 1988;10:259–268.

    Article  PubMed  CAS  Google Scholar 

  30. Bonnevie O. Changing demographics of peptic ulcer disease. Dig Dis Sci 1985;30(suppl):8S.

    Article  Google Scholar 

  31. Kurata JH, Haile BM, Elashoff JD. Sex differences in peptic ulcer disease. Gastroenterology 1985;88:96–100.

    PubMed  CAS  Google Scholar 

  32. Cryer B, Feldman M. Peptic ulcer disease in the elderly. Semin Gastrointest Dis 1994;5:166–178.

    PubMed  CAS  Google Scholar 

  33. Gilinsky NH. Peptic ulcer disease in the elderly. Scand J Gastroenterol 1988;23(suppl 146):191–200.

    Article  Google Scholar 

  34. Green L, Graham D. Gastritis in the elderly. Gastroenterol Clin North Am 1990;19:273–292.

    PubMed  CAS  Google Scholar 

  35. Siurala M, Krohn K, Varis K. Parietal cell and intrinsic factor antibodies in a Finnish rural population sample. Scand J Gastroenterol 1969;4:521–527.

    Article  PubMed  Google Scholar 

  36. Siurala M, Salmi HJ. Long term follow-up of subjects with superficial gastritis or normal gastric mucosa. Scand J Gastroenterol 1971;6:459–463.

    Article  PubMed  CAS  Google Scholar 

  37. Siurala M, Lehtola J, Ihamaki T. Atrophic gastritis and its sequelae: results of 19–23 years of follow-up examinations. Scand J Gastroenterol 1974;9:441–446.

    PubMed  CAS  Google Scholar 

  38. Cotran RS, Kumar V, Robbins SL (eds). Robbins’ Pathologic Basis of Disease. Philadelphia: Saunders, 1989:844.

    Google Scholar 

  39. Rauws EA, Langenberg W, Houthoff HJ, Zanen HC, Tytgat GNJ. Campylobacter pyloris-associated chronic active antral gastritis: a prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Gastroenterology 1988;94:33–40.

    PubMed  CAS  Google Scholar 

  40. Safe AF, Warren B, Corfield A, et al. Helicobacter pylori infection in elderly people: correlation between histology and serology. Age Ageing 1993;22:215–220.

    Article  PubMed  CAS  Google Scholar 

  41. Gillanders IA, Scott PJW, Smith GD. Helicobacter pylori and chronic antral gastritis in elderly patients. Age Ageing 1994;23:277–279.

    Article  PubMed  CAS  Google Scholar 

  42. Levitan R. GI problems in the elderly. Part I. Aging-related considerations. Geriatrics 1989;44(9):53–56.

    PubMed  CAS  Google Scholar 

  43. Levitan R. GI problems in the elderly. Part II. Prevalent diseases and disorders. Geriatrics 1989;44(11):80–86.

    PubMed  CAS  Google Scholar 

  44. Dooley CA, Cohen H, Fitzgibbons PL, et al. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med 1987;321:1562–1566.

    Article  Google Scholar 

  45. Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and risk of gastric cancer. N Engl J Med 1991;325:1127–1131.

    Article  PubMed  CAS  Google Scholar 

  46. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Isaacson PG. Helicobacter pylori associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175–1176.

    Article  PubMed  CAS  Google Scholar 

  47. Klein PD, Graham DY, Gaillour A, et al. Water source as risk factor for Helicobacter pylori infection in Peruvian children. Lancet 1991;337:1503–1506.

    Article  PubMed  CAS  Google Scholar 

  48. Graham DY, Malaty HM, Evans DG, Evans DJ Jr, Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States: effect of age, race and socioeconomic status. Gastroenterology 1991; 100:1495–1501.

    PubMed  CAS  Google Scholar 

  49. Perez-Perez GI, Dworkin BM, Chodos JE, Blaser MJ. Campylobacter pylori antibodies in humans. Ann Intern Med 1988;109:11–17.

    Article  PubMed  CAS  Google Scholar 

  50. Cullen DJ, Collins BJ, Christiansen KJ, et al. When is Helicobacter pylori infection acquired? Gut 1993;12:1681–1682.

    Article  Google Scholar 

  51. Fiedorek SC, Evans DG, Evans DJ, et al. H. pylori infection epidemiology in children: importance of socioeconomic status, age, gender, and race. Gastroenterology 1990;98: A44.

    Google Scholar 

  52. Mendall MA, Goggin PM, Molineaux N, et al. Childhood living conditions and Helicobacter pylori seropositivity in adult life. Lancet 1992;85:944–948.

    Google Scholar 

  53. Lee A. The microbiology and epidemiology of Helicobacter pylori infection. Scand J Gastroenterol 1994;29(suppl 201):2–6.

    Article  Google Scholar 

  54. Morris A, Nicholson G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol 1987;82:192–199.

    PubMed  CAS  Google Scholar 

  55. Jiang SJ, Liu WZ, Zhang DZ, et al. Campylobacter-like organisms in chronic gastritis, peptic ulcer, and gastric carcinoma. Scand J Gastroenterol 1987;22:553–558.

    Article  PubMed  CAS  Google Scholar 

  56. Ateshkadi A, Lam NP, Johnson CA. Helicobacter pylori and peptic ulcer disease. Clin Pharmacokinet 1993;12: 34–48.

    CAS  Google Scholar 

  57. Tytgat GNJ. Peptic ulcer and Helicobacter pylori: eradication and relapse. Scand J Gastroenterol 1995;30(suppl 210):70–72.

    Article  Google Scholar 

  58. Forbes GM, Glaser ME, Cullen DJ, et al. Duodenal ulcer treated with Helicobacter pylori eradication: seven-year follow-up. Lancet 1994;343:258–260.

    Article  PubMed  CAS  Google Scholar 

  59. Roth SH. Nonsteroidal anti-inflammatory drugs: gastropathy deaths and medical practice. Ann Intern Med 1988;109:353–354.

    Article  PubMed  CAS  Google Scholar 

  60. Beard K, Walker AM, Perera DR, Jicks H. Nonsteroidal anti-inflammatory drugs and hospitalization for gastroesophageal bleeding in the elderly. Arch Intern Med 1987; 47:1621–1623.

    Article  Google Scholar 

  61. Henry D, Robertson J. Nonsteroidal anti-inflammatory drugs and peptic ulcer hospitalization rates in New South Wales. Gastroenterology 1993;104:1083–1091.

    PubMed  CAS  Google Scholar 

  62. Fries JF, Miller SR, Spitz PW, Williams CA, Hubert HB, Bloch DA. Toward an epidemiology of gastropathy associated with nonsteroidal anti-inflammatory drug use. Gastroenterology 1989;96:647–655.

    PubMed  CAS  Google Scholar 

  63. Roth SH, Bennett RE. Nonsteroidal anti-inflammatory drug gastropathy: recognition and response. Arch Intern Med 1987;147:2093–2100.

    Article  PubMed  CAS  Google Scholar 

  64. Bellary SV, Isaacs PE, Lee FT. Upper gastrointestinal lesions in elderly patients presenting for endoscopy: relevance of NSAID usage. Am J Gastroenterol 1991;86:961–964.

    PubMed  CAS  Google Scholar 

  65. Hochberg MC. Association of nonsteroidal antiinflammatory drugs with upper gastrointestinal disease: epidemiologic and economic considerations. J Rheumatol 1992;19(suppl 36):63–67.

    Google Scholar 

  66. Armstrong CP, Blower AL. Nonsteroidal antiinflammatory drugs and life threatening complications of peptic ulceration. Gut 1987;28:527–532.

    Article  PubMed  CAS  Google Scholar 

  67. Griffen MR, Piper JM, Daugherty JR, Snowden M, Ray WA. Nonsteroidal antiinflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991;114:257–263.

    Article  Google Scholar 

  68. Griffen MR, Ray WA, Schaffner W. Nonsteroidal antiinflammatory drug use and death from peptic ulcer in elderly persons. Ann Intern Med 1988;109:359–363.

    Article  Google Scholar 

  69. Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. Ann Intern Med 1991; 115:787–796.

    Article  PubMed  CAS  Google Scholar 

  70. Levine MN, Raskob G, Hirsh J. Hemorrhagic complications of long-term anticoagulant therapy. Chest 1989;95: 26S-36S.

    PubMed  CAS  Google Scholar 

  71. Shorr RI, Ray WA, Daugherty JR, Griffen MR. Concurrent use of nonsteroidal antiinflammatory drugs and oral anticoagulants place elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med 1993;153: 1665–1670.

    Article  PubMed  CAS  Google Scholar 

  72. Chiverton SG, Hunt RH. Pharmacokinetics and pharmacodynamics of treatments for peptic ulcer disease in the elderly. Am J Gastroenterol 1988;83:211–215.

    PubMed  CAS  Google Scholar 

  73. Koop H, Arnold R, Classen M, Fischer M, Goebell H, Blum AL. Healing and relapse of duodenal ulcer during ranitidine therapy in the elderly: the Ruder Study Group. J Clin Gastroenterol 1992;15:291–295.

    Article  PubMed  CAS  Google Scholar 

  74. Sirgo MA, Mills R, Euler AR, Walker S. The safety of ranitidine in elderly versus nonelderly patients. J Clin Pharmacol 1993;33:79–83.

    Article  PubMed  CAS  Google Scholar 

  75. Humphries TJ, Myerson RM, Gifford LM, et al. A unique postmarket outpatient surveillance program of Cimetidine: report on phase II and final summary. Am J Gastroenterol 1984;79:593–596.

    PubMed  CAS  Google Scholar 

  76. Isenberg JI. Should safety concerns with available ulcer treatment influence drug selection. J Clin Gastroenterol 1990;12(suppl 2):S48-S53.

    Article  PubMed  Google Scholar 

  77. Lacz JP, Groschang AG, Giesing DH, Browne RK. The effect of sucralfate on drug absorption in dogs [abstract]. Gastroenterology 1982;82:1108.

    Google Scholar 

  78. Graham DY, Agrawal NM, Roth SH. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double blind, placebo-controlled trial. Lancet 1988;2: 1277–1280.

    Article  PubMed  CAS  Google Scholar 

  79. McKenna F. Efficacy and gastroduodenal safety of a fixed combination of diclofenac and misoprostol in the treatment of arthritis. Br J Rheumatol 1995;34(suppl 1):11–18.

    Article  PubMed  Google Scholar 

  80. Maton PN. Omeprazole. N Engl J Med 1991;324:965–975.

    Article  PubMed  CAS  Google Scholar 

  81. Graham DY, Colon-Pagan J, Morse RS, et al. Ulcer recurrence following duodenal ulcer healing with omeprazole, ranitidine, or placebo: a double-blind, multicenter, 6-month study. Gastroenterology 1992;102:1289–1294.

    PubMed  CAS  Google Scholar 

  82. Hunt RH. Helicobacter pylori eradication: a critical appraisal and current concerns. Scand J Gastroenterol 1995;30(suppl 210):73–76.

    Article  Google Scholar 

  83. Chiba N, Rao BV, Rademaker JW, et al. Meta-analysis of the efficacy of antibiotic therapy in eradicating H. pylori. Am J Gastroenterol 1992;87:1716–1722.

    PubMed  CAS  Google Scholar 

  84. Cutler AF, Schubert TT. Long-term Helicobacter pylori recurrence after successful eradication with triple therapy. Am J Gastroenterol 1993;88:1359–1361.

    PubMed  CAS  Google Scholar 

  85. Unge P, Ekstrom P. Effects of combination therapy with omeprazole and an antibiotic on Helicobacter pylori and duodenal ulcer disease. Scand J Gastroenterol 1993; 28(suppl 196):17–18.

    Article  Google Scholar 

  86. Bayerdorffer E, Mannes GA, Sommer A, et al. Long-term follow-up after eradication of Helicobacter pylori with a combination of omeprazole and amoxicillin. Scand J Gastroenterol 1993;28(suppl 196):19–25.

    Article  Google Scholar 

  87. Paimela H, Tuompo PK, Perakyla T, Saario I, Hockerstedt K, Kivilaakso E. Peptic ulcer surgery during the H2-receptor antagonist era: a population-based epidemiological study of ulcer surgery in Helsinki from 1972–1987. Br J Surg 1991;78:28–31.

    Article  PubMed  CAS  Google Scholar 

  88. Gustavsson S, Kelly KA, Melton LJ III, Zinsmeister AR. Trends in peptic ulcer surgery: a population-based study in Rochester, Minnesota, 1956–1985. Gastroenterology 1988;94:688–694.

    PubMed  CAS  Google Scholar 

  89. Welch CE, Rodkey GV, von Ryll Gryska P. A thousand operations for ulcer disease. Ann Surg 1986;204:454–467.

    Article  PubMed  CAS  Google Scholar 

  90. Walker LG Jr. Trends in the surgical management of duodenal ulcer: a fifteen year study. Am J Surg 1988; 155:436–438.

    Article  PubMed  Google Scholar 

  91. McConnell DB, Baba GC, Deveney CW. Changes in surgical treatment of peptic ulcer disease within a veterans hospital in the 1970s and the 1980s. Arch Surg 1989;124: 1164–1167.

    Article  PubMed  CAS  Google Scholar 

  92. Boey J, Choi SKY, Alagaratnam TT. Risk stratification in perforated duodenal ulcers: a prospective validation of predictive factors. Ann Surg 1987;205:22–26.

    Article  PubMed  CAS  Google Scholar 

  93. Hamby LS, Zweng TN, Strodel WE. Perforated gastric and duodenal ulcer: an analysis of prognostic factors. Am Surg 1993;59:320–324.

    Google Scholar 

  94. Boey J, Wong J. Perforated duodenal ulcers. World J Surg 1987;11:319–324.

    Article  PubMed  CAS  Google Scholar 

  95. Feliciano DV, Bitondo CG, Burch JM, Mattox KL, Jordan GL Jr, DeBakey ME. Emergency management of perforated peptic ulcers in the elderly patient. Am J Surg 1984;148: 764–767.

    Article  PubMed  CAS  Google Scholar 

  96. Hodnett RM, Gonzalez F, Lee C, Nance FC, Deboisblanc R. The need for definitive therapy in the management of perforated gastric ulcers: review of 202 cases. Ann Surg 1989; 209:36–39.

    Article  PubMed  CAS  Google Scholar 

  97. Kane E, Fried G, McSherry CK. Perforated peptic ulcer in the elderly. J Am Geriatr Soc 1981;29:224–227.

    PubMed  CAS  Google Scholar 

  98. Bliss DW, Stabile BE. The impact of ulcerogenic drugs on surgery for the treatment of peptic ulcer disease. Arch Surg 1991;126:609–612.

    Article  PubMed  CAS  Google Scholar 

  99. Svanes C, Salvesen H, Espehaug B, Soreide O, Svanes K. A multifactorial analysis of factors related to lethality after treatment of perforated gastroduodenal ulcer: 1935–1985. Ann Surg 1989;209:418–423.

    Article  PubMed  CAS  Google Scholar 

  100. Mendes da Costa PR, Lurquin P. Gastrointestinal surgery in the aged. Br J Surg 1993;80:329.

    Article  PubMed  CAS  Google Scholar 

  101. Permutt RP, Cello JP. Duodenal ulcer disease in the hospitalized elderly patient. Dig Dis Sci 1982;27:1–6.

    Article  PubMed  CAS  Google Scholar 

  102. Matthewson K, Pugh S, Northfield TC. Which peptic ulcer patients bleed? Gut 1988;29:70–74.

    Article  PubMed  CAS  Google Scholar 

  103. McFadden DW, Zinner MJ. Gastroduodenal disease in the elderly patient. Surg Clin North Am 1994;74:113–126.

    PubMed  CAS  Google Scholar 

  104. Morris DL, Hawker PC, Brearly S, et al. Optimal timing of operation for bleeding peptic ulcer: prospective randomized trial. BMJ 1984;74:1277–1280.

    Article  Google Scholar 

  105. Branicki FJ, Boey J, Fok PJ, et al. Bleeding duodenal ulcer: a prospective evaluation of risk factors for rebleeding and death. Ann Surg 1990;211:411–418.

    Article  PubMed  CAS  Google Scholar 

  106. McGuire HH, Horsley JS. Emergency operations for gastric and duodenal ulcers in high risk patients. Ann Surg 1986; 203:551–557.

    Article  PubMed  Google Scholar 

  107. Boey J, Lee NW, Koo J, Lam PHM, Wong J, Ong GB. Immediate definitive surgery for perforated duodenal ulcers: a prospective controlled trial. Ann Surg 1982;196: 338–344.

    Article  PubMed  CAS  Google Scholar 

  108. Hunt PS. Bleeding gastroduodenal ulcers: selection of patients for surgery. World J Surg 1987;11:289–294.

    Article  PubMed  CAS  Google Scholar 

  109. Lamers CB, Bijlstra AM, Haris AG. Octreotide, a long-acting somatostatin analog: in the management of postoperative dumping syndrome. Dig Dis Sci 1993;38: 359–364.

    Article  PubMed  CAS  Google Scholar 

  110. Sawyers JL. Management of postgastrectomy syndromes. Am J Surg 1990;159:8–14.

    Article  PubMed  CAS  Google Scholar 

  111. Hoffmann J, Jensen HE, Christiansen J, et al. Prospective controlled vagotomy trial for duodenal ulcer: results after 11–15 years. Ann Surg 1989;209:40–45.

    Article  PubMed  CAS  Google Scholar 

  112. Hoffmann J, Shokouh-Amiri MH, Klarskov P, et al. Gastrectomy for recurrent ulcer after vagotomy: five- to nineteen-year follow-up. 1986;99:517–522.

    CAS  Google Scholar 

  113. Kaushik SP, Ralphs DN, Hobsley M. Influences on the occurrences of dumping syndrome. Am J Gastroenterol 1983;78:155–158.

    PubMed  CAS  Google Scholar 

  114. Geer RJ, Richards WO, O’Dorisio TM, et al. Efficacy of octreotide acetate in treatment of severe postgastrectomy dumping syndrome. Ann Surg 1990;212:678.

    Article  PubMed  CAS  Google Scholar 

  115. Herrington JL, Scott HW, Sawyers JL. Experience with vagotomy and antrectomy and Roux-en-Y gastrojejunostomy in the surgical treatment of duodenal, gastric and stomal ulcers. Ann Surg 1984;199:590–597.

    Article  PubMed  Google Scholar 

  116. Vellar DJ, Vellar ID, Pucius R, et al. Phytobezoars: an overlooked cause of small bowel obstruction following vagotomy and drainage operations for duodenal ulcer. Aust NZ J Surg 1986;56:635–638.

    Article  CAS  Google Scholar 

  117. Robles R, Parrilla P, Escamilla C, et al. Gastrointestinal bezoars. Br J Surg 1994;81:1000–1001.

    Article  PubMed  CAS  Google Scholar 

  118. Rider JA, Foresti-Lorente RJ, Garrido J, et al. Gastric bezoars: treatment and prevention. Am J Gastroenterol 1984;79:357–359.

    PubMed  CAS  Google Scholar 

  119. Klamer TW, Max MH. Recurrent gastric bezoars: a new approach to treatment and prevention. Am J Surg 1983;145: 417–419.

    Article  PubMed  CAS  Google Scholar 

  120. Krausz MM, Moriel EZ, Ayalon A, et al. Surgical aspects of gastrointestinal persimmon phytobezoar treatment. Am J Surg 1986;152:526–530.

    Article  PubMed  CAS  Google Scholar 

  121. Visvanathan R. Cement bezoars of the stomach. Br J Surg 1986;73:381–382.

    Article  PubMed  CAS  Google Scholar 

  122. Lanza FL. Benign and malignant tumors of the stomach other than carcinoma. In: Haubrich WS, Schaffner F, Bertk JE (eds) Bockus Gastroenterology, 5th ed. Philadelphia: Saunders, 1995:841–858.

    Google Scholar 

  123. Morgan BK, Compton C, Talbert M, et al. Benign smooth muscle tumors of the gastrointestinal tract: a 24-year experience. Ann Surg 1990;211:63–66.

    Article  PubMed  CAS  Google Scholar 

  124. Motson RW, Fisher PW, Dawson JW. Laparoscopic resection of a benign intragastric stromal tumor. Br J Surg 1995;82:1670.

    Article  PubMed  CAS  Google Scholar 

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Cima, R.R., Soybel, D.I. (2001). Pathophysiology and Treatment of Benign Diseases of the Stomach and Duodenum. In: Rosenthal, R.A., Zenilman, M.E., Katlic, M.R. (eds) Principles and Practice of Geriatric Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3432-4_39

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