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Principles and Practice of Geriatric Surgery pp 325–330Cite as

Physiologic Changes and Benign Perimenopausal Breast Disease

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Abstract

Familiarity with breast microanatomy and physiology aids in understanding benign breast physiology The female breast is composed of ductal and lobular units. The main breast ducts arise from lactiferous sinuses in the nipple and divide several times to form small ducts and then the smallest ductal elements, or “ductules,” which in fact form the lobular unit of the breast. The ductules also divide and terminate blindly with club-shaped endings. The ductules are sensitive to hormonal stimulation; during pregnancy they proliferate and form the alveolar components of the breast.1

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References

  1. Parks AG. The microanatomy of the breast. Ann R Coll Surg 1959;25:235–251.

    CAS  Google Scholar 

  2. Anbazhagan R, Bartek J, Monaghan P, Gusteron BA. Growth and development of the human infant breast. Am J Anat 1991;192:407–417.

    Article  PubMed  CAS  Google Scholar 

  3. Reyniak JV. Endocrine physiology of the breast. J Reprod Med 1979;22:303–309.

    PubMed  CAS  Google Scholar 

  4. Vorherr H. Menopausal mammary involution. In: The Breast. Morphology, Physiology and Lactation. Academic: San Diego, 1974:215–217.

    Google Scholar 

  5. Tavossoli FA. Postmenopausal involution (atrophy). In: Pathology of the Breast. Elsevier: New York, 1992:20.

    Google Scholar 

  6. Devitt JE. Benign disorders of the breast in older women. Surg Gynecol Obstet 1996;162:340–342.

    Google Scholar 

  7. Gateley CA, Mansel RE. Management of the painful and nodular breast. Br Med Bull 1991;47:284–294.

    PubMed  CAS  Google Scholar 

  8. Bengtsson C. Aspects of hormone replacement therapy in the post menopause. Maturitas 1989;11:35–41.

    Article  PubMed  CAS  Google Scholar 

  9. Marsh MS, Whitcroft S, Whitehead MI. Paradoxical effects of hormone replacement therapy on breast tenderness in postmenopausal women. Maturitas 1994; 19:97–102.

    Article  PubMed  CAS  Google Scholar 

  10. Ryan PJ, Harrison R, Blake GM, Fogelman I. Compliance with hormone replacement therapy (HRT) after screening for postmenopausal osteoporosis. Br J Obstet Gynaecol 1992;99:325–328.

    Article  PubMed  CAS  Google Scholar 

  11. Holland P, Gateley C. Drug therapy of mastalgia: what are the options? Drugs 1994;48:709–716.

    Article  PubMed  CAS  Google Scholar 

  12. Kern WH, Clark RW. Retrogression of fibroadenomas of the breast. Am J Surg 1973;126:59–56.

    Article  PubMed  CAS  Google Scholar 

  13. Hunter TB, Roberts CC, Hunt R, Fajardo LL. Occurrence of fibroadenomas in postmenopausal women referred for breast biopsy. J Am Geriatr Soc 1996;44:61–64.

    PubMed  CAS  Google Scholar 

  14. Dixon JM. Cystic disease and fibroadenoma of the breast: natural history and relation to breast cancer risk. Br Med Bull 1991;47:258–271.

    PubMed  CAS  Google Scholar 

  15. Egan R. Fibroadenoma. In: Breast Imaging. Diagnosis and Morphology of Breast Diseases. Saunders: Philadelphia, 1988:178–182.

    Google Scholar 

  16. Sandison AT. Fibroadenoma: an autopsy study of the adult human breast. Natl Cancer Inst Monogr 1962;8:30.

    Google Scholar 

  17. Frantz VK, Pickren JW, Melcher GW, Auchincloss H. Incidence of chronic cystic disease in so-called “normal breasts”: a study based on 225 postmortem examinations. Cancer 1951;4:762–783.

    Article  PubMed  CAS  Google Scholar 

  18. Kopans DB. Benign and probably benign lesions. In: Breast Imaging. Lippincot-Raven: Philadelphia, 1998:351– 373.

    Google Scholar 

  19. Rosen PP. Mammary duct ectasia. In: Rosen’s Breast Pathology. Lippincot-Raven: Philadelphia, 1997:29–32.

    Google Scholar 

  20. Hughes LE. Nonlactational inflammation and duct ectasia. Br Med Bull 1991;47:272–283.

    PubMed  CAS  Google Scholar 

  21. Dixon JM, Anderson TJ , Lumsden AB, Elton RA, Roberts MM, Forrest APM. Mammary duct ectasia. Br J Surg 1983; 70:601–603.

    Article  PubMed  CAS  Google Scholar 

  22. Dixon JM, Ravisekar O, Chetty U, Anderson TJ. Periductal mastitis and duct ectasia: different conditions with different aetiologies. Br J Surg 1996;83:820–822.

    Article  PubMed  CAS  Google Scholar 

  23. Martin JE. Benign diseases of the breast. In: Harris JH Jr (ed) Atlas of Mammography. Histologic and Mammographic Correlations. Williams & Wilkins: Baltimore, 1982:192–195.

    Google Scholar 

  24. Sandison A. Atrophy, duct ectasia and cyst formation: an autopsy study of the adult human breast. Natl Cancer Inst Monogr 1962;8:11–16.

    Google Scholar 

  25. Heywang-Kobrunger SH, Scherer I, Dershaw DD. Benign Breast Disorders. Thieme: Stuttgart, 1997:141–165.

    Google Scholar 

  26. Laya MB, Gallagher JC, Schreiman JS, Larson EB, Watson P, Weinstein L. Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern. Radiology 1995;196:433–437.

    PubMed  CAS  Google Scholar 

  27. Wolfe JN. Breast parenchymal patterns and their changes with age. Radiology 1976;121:545–552.

    PubMed  CAS  Google Scholar 

  28. Peck DR, Lowman RM. Estrogen and the postmenopausal breast: mammographie considerations. JAMA 1978;240: 1733–1735.

    Article  PubMed  CAS  Google Scholar 

  29. Stomper PC, Voorhis BJV, Ravnikar VA, Meyer JE. Mammographie changes associated with postmenopausal hormone replacement therapy: a longitudinal study. Radiology 1990;174:487–490.

    PubMed  CAS  Google Scholar 

  30. Persson I, Thurfjell E, Holmberg L. Effect of estrogen and estrogen-progestin replacement regimens on mammographie breast parenchymal density. J Clin Oncol 1997;15: 3201–3207.

    PubMed  CAS  Google Scholar 

  31. Berkowitz JE, Gatewood OMB, Goldblum LE, Gayler BW. Hormonal replacement therapy: mammographie manifestations. Radiology 1990;174:199–201.

    PubMed  CAS  Google Scholar 

  32. Martin JE. Benign calcifications. In: Harris JH Jr (ed) Atlas of Mammography. Histologie and Mammographie Correlations. Williams & Wilkins: Baltimore, 1982:196–209.

    Google Scholar 

  33. Cooper RA, Gunter BA, Ramamurthy L. Mammography in men. Radiology 1994;191:651–656.

    PubMed  CAS  Google Scholar 

  34. Williams MJ. Gynecomastia. Am J Med 1963;34:103–112.

    Article  PubMed  CAS  Google Scholar 

  35. Neuman JE Evaluation and treatment of gynecomastia. Am Farn Physician 1997;55:1835–1844.

    CAS  Google Scholar 

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Authors
  1. Sancar Bayar
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  2. Barbara A. Ward
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Editor information

Editors and Affiliations

  1. Department of Surgery, Yale University School of Medicine, New Haven, CT, 06520, USA

    Ronnie A. Rosenthal MD (Associate Professor, Chief, Surgical Service) (Associate Professor, Chief, Surgical Service)

  2. Department of Veterans Affairs, VA Connecticut Healthcare System, West Haven, 06516, CT, USA

    Ronnie A. Rosenthal MD (Associate Professor, Chief, Surgical Service) (Associate Professor, Chief, Surgical Service)

  3. Department of Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, 10461, NY, USA

    Michael E. Zenilman MD (Associate Professor and Vice-Chairman, Chief of Surgery) (Associate Professor and Vice-Chairman, Chief of Surgery)

  4. Jack D. Weiler Hospital of the Albert Einstein College of Medicine, Bronx, 10461, NY, USA

    Michael E. Zenilman MD (Associate Professor and Vice-Chairman, Chief of Surgery) (Associate Professor and Vice-Chairman, Chief of Surgery)

  5. Wyoming Valley Surgical Associates, Kingston, 18704, PA, USA

    Mark R. Katlic M.D. (Chief of Thoracic Surgery) (Chief of Thoracic Surgery)

  6. Wyoming Valley Healthcare System, Wilkes-Barre, 18702, PA, USA

    Mark R. Katlic M.D. (Chief of Thoracic Surgery) (Chief of Thoracic Surgery)

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© 2001 Springer Science+Business Media New York

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Bayar, S., Ward, B.A. (2001). Physiologic Changes and Benign Perimenopausal Breast Disease. In: Rosenthal, R.A., Zenilman, M.E., Katlic, M.R. (eds) Principles and Practice of Geriatric Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3432-4_23

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  • DOI: https://doi.org/10.1007/978-1-4757-3432-4_23

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-3434-8

  • Online ISBN: 978-1-4757-3432-4

  • eBook Packages: Springer Book Archive

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