Endocrinology and Aging

  • Hosam K. Kamel
  • John E. Morley


In 1889 C.E. Brown-Sequard, a noted French scientist, claimed that a water-soluble extract of dog testes gave him an “astonishing degree of rejuvenation” and improved his long-standing problems with impotence.1 Although we now know that there was minimal testosterone or other sex steroids in this water-soluble extract, the link between hormones and aging was clearly postulated. Over the past century our understanding of hormonal changes with age and the effect of hormonal repletion in elderly individuals has increased dramatically. It is now well established that aging is associated with a host of changes in the endocrine system (Table 20.1). At present, it is not completely clear whether these age-related changes aggravate the alterations in various biologic functions that accompany aging or are compensatory events that minimize tissue damage and conserve organ vitality. This chapter reviews the age-related changes in the endocrine system.


Luteinizing Hormone Estrogen Replacement Therapy Subclinical Hypothyroidism Multinodular Goiter Dehydroepiandrosterone Sulfate 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Hosam K. Kamel
  • John E. Morley

There are no affiliations available

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