Abstract
The preparation of macromolecular conjugates of dextran, which could be used in the design of in perfusion contrast agents for Magnetic Resonance Angiography (MRA), is described. In a first step, an amino group was introduced in the diethylenetriamine pentaacetic acid (DTPA) structure, in order to obtain a complex with one linking group. The derivatized DTPA was characterized by NMR, and subsequently covalently linked to dextran using carbonyldiimidazole (CDI) as an activating agent. The degree of substitution of macromolecular conjugates of dextran can be tuned by the molar ratio of CDI/dextran applied.
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Duarte, M.G., Geraldes, C.F.G.C., Peters, J.A., Gil, M.H. (2001). Preparation of Dextran-Based Macromolecular Chelates for Magnetic Resonance Angiography. In: Chiellini, E., Gil, H., Braunegg, G., Buchert, J., Gatenholm, P., van der Zee, M. (eds) Biorelated Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3374-7_19
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DOI: https://doi.org/10.1007/978-1-4757-3374-7_19
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