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Diagnosis and Management of Intrahepatic and Extrahepatic Cholangiocarcinoma

  • Chapter
Liver-Directed Therapy for Primary and Metastatic Liver Tumors

Part of the book series: Cancer Treatment and Research ((CTAR,volume 109))

Abstract

Cholangiocarcinomas are malignant tumors that arise from the epithelium of the intrahepatic or extrahepatic bile ducts. Cholangiocarcinomas are rare compared with hepatocellular carcinoma, comprising less than 10% of primary malignancies of the liver (1). In the United States, approximately 3,000 patients are diagnosed with cholangiocarcinoma annually (2). The autopsy incidence of cholangiocarcinoma is low also, being reported in 0.089–0.46% of necropsies (1). Cholangiocarcinomas are diagnosed most frequently in the fifth and sixth decades of life (3). There is only a slight male preponderance of cases of cholangiocarcinoma. Cholangiocarcinomas can arise at any site in the intra- or extrahepatic biliary system, but perihilar tumors comprise two-thirds of the cases of cholangiocarcinoma (3) (Fig. 1).

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  1. The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Steven A. Curley M.D., F.A.C.S.

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  1. Northwestern University Medical School, Chicago, IL, USA

    Mark S. Talamonti M.D.  & Sam G. Pappas M.D.  & 

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Curley, S.A. (2001). Diagnosis and Management of Intrahepatic and Extrahepatic Cholangiocarcinoma. In: Talamonti, M.S., Pappas, S.G. (eds) Liver-Directed Therapy for Primary and Metastatic Liver Tumors. Cancer Treatment and Research, vol 109. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3371-6_7

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