Diagnosis and Management of Intrahepatic and Extrahepatic Cholangiocarcinoma

  • Steven A. Curley
Part of the Cancer Treatment and Research book series (CTAR, volume 109)


Cholangiocarcinomas are malignant tumors that arise from the epithelium of the intrahepatic or extrahepatic bile ducts. Cholangiocarcinomas are rare compared with hepatocellular carcinoma, comprising less than 10% of primary malignancies of the liver (1). In the United States, approximately 3,000 patients are diagnosed with cholangiocarcinoma annually (2). The autopsy incidence of cholangiocarcinoma is low also, being reported in 0.089–0.46% of necropsies (1). Cholangiocarcinomas are diagnosed most frequently in the fifth and sixth decades of life (3). There is only a slight male preponderance of cases of cholangiocarcinoma. Cholangiocarcinomas can arise at any site in the intra- or extrahepatic biliary system, but perihilar tumors comprise two-thirds of the cases of cholangiocarcinoma (3) (Fig. 1).


Bile Duct Primary Sclerosing Cholangitis Hepatic Duct Choledochal Cyst Extrahepatic Bile Duct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Steven A. Curley
    • 1
  1. 1.The University of Texas M.D. Anderson Cancer CenterHoustonUSA

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