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Clinical Features of Primary and Metastatic Hepatic Malignancies

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Liver-Directed Therapy for Primary and Metastatic Liver Tumors

Part of the book series: Cancer Treatment and Research ((CTAR,volume 109))

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Abstract

In the United States, it is estimated that 1,268,000 new cancer cases will be diagnosed in the year 2001. Approximately 550,000 cancer-related deaths will occur in the same time period (1). Cancers with the liver as a major site of disease involvement will constitute a significant portion (16,200 new cases) of these new cancer cases. Of concern is the typically poor response of primary liver tumors and hepatic metastases to conventional therapies. However, more aggressive operative strategies and the expanding use of regional and systemic chemotherapeutic approaches have led to more treatment options for tumors of the liver.

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References

  1. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer Statistics, 2001. CA Cancer J. Clin 2001 51: 15–36.

    Article  PubMed  CAS  Google Scholar 

  2. Parkin D, Pisani P, Ferlay J. Global Cancer Statistics. CA Cancer J. Clin 1999: 49(1) 33–64.

    Article  PubMed  CAS  Google Scholar 

  3. Sitzmann JV. Malignant Liver Tumors. Current Surgical Therapy. St. Louis, Missouri: Mosby, Inc, Cameron JL. (6th edition) 1998: 343–346.

    Google Scholar 

  4. El-Serag HB, Mason AC. Rising Incidence of Hepatocellular Carcinoma in the United States. N Engl J Med 1999; 340:10 pp 745–750.

    Article  PubMed  CAS  Google Scholar 

  5. Cortes-Espinosa T, Mondragon-Sanchez R, Hurtado-Andrade H, et al. Hepatocellular Carcinoma and Hepatic Cirrhosis in Mexico. A 25-year Necroscopy Review. Hepto Gastroenterology 1997; 44:1401–1403.

    CAS  Google Scholar 

  6. Reynolds T. Global Cancer Burden Difficult to Assess, Rising Rates Likely. Journal of the Nat’l Cancer Inst 1998; 90(10):734–746.

    Article  CAS  Google Scholar 

  7. Di Bisceglie A, Carithers R, Gores G. Hepatocellular Carcinoma. Hepatology 1998; 28(4) 1161–1165.

    Article  PubMed  Google Scholar 

  8. Schafer DF, Sorrell MF. Hepatocellular carcinoma. Lancet 1999; 353:125357.

    Google Scholar 

  9. Beasley RP, Hwang LY, Lin CC, Chein CS. Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22 707 men in Taiwan. Lancet 1981; ii: 1129–33.

    Article  Google Scholar 

  10. Beebe GW, Norman JE. Study of the likelihood of hepatocellular carcinoma following the 1942 Army epidemic of hepatitis B. In: Tabor E, Di Bisceglie AM, Purcell RH,eds. Etiology, pathology, and treatment of hepatocellular carcinoma in North America. Houston:Gulf Publishing, 1991:3–13.

    Google Scholar 

  11. Lasky T, Magder L. Hepatocellular carcinoma p53 G-→T transversions at codon 249: the fingerprint of aflatoxin exposure? Environ Health Perspect 1997; 105:392–97.

    PubMed  CAS  Google Scholar 

  12. Cottone M, Turri M, Caltagirone M, et al. Screening for hepatocellular carcinoma in patients with Child’s A cirrhosis: an 8 year prospective study by ultrasound and alfafetoprotein. J Hepatoll 1994; 21:1029–34.

    Article  CAS  Google Scholar 

  13. Chang MH, Chen CJ, Lai MS, et al. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. N Engl J Med 1997; 336:1855–59.

    Article  PubMed  CAS  Google Scholar 

  14. Muto Y, Moriwaki H, Niomiya M, et al. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. N Engl J Med 1996; 334: 1561–67.

    Article  PubMed  CAS  Google Scholar 

  15. Araki H, Shidoji M, Yamada Y, Moriwaki H, Muto Y. Retinoid agonist activities of synthetic geranyl geranoic acid derivatives. Biochem Biophys Res Commun 1995; 209:66–72.

    Article  PubMed  CAS  Google Scholar 

  16. Hatekeyama H, Shidoji Y, Omori M, et al. Retardation effect of acyclic retinoid on spontaneous hepatocarcinogenesis without changes in incidence of c-Ha-ras mutations in C3H/HeNCrj mice. Center Detect Prey (in press).

    Google Scholar 

  17. Pitt HA, Dooley WC, Yeo CJ et al. Malignancies of the biliary tract. Curr Probl Surg 1995:32:1.

    Article  PubMed  CAS  Google Scholar 

  18. Miller BA, Ries LAG, Hankey BF, et al. SEER Cancer statistics review: 1973–1990. (NIH Publication No. 93–2789). Bethesda, Md: National Cancer Institute, 1993.

    Google Scholar 

  19. Waterhouse JC, Muir P, Correa S. Cancer incidence in five countries. Lyon (France): V03 TARC Scientific Publishers, International Agency for Research in Cancer, 1976.

    Google Scholar 

  20. Sheen-Chen SM, Chou FF, Eng HL. Intrahepatic cholangiocarcinoma in hepatolithiasis: a frequently overlooked disease. J Surg Oncol 1991; 47:131–5.

    Article  PubMed  CAS  Google Scholar 

  21. Fan ST, Lai EC, Wong J. Hepatic resection for hepatolithiasis. Arch Surg 1993; 128:1070–4.

    Article  PubMed  CAS  Google Scholar 

  22. Chijiiwa K, Ichimiya H, Kuroki S, et al. Late development of cholangiocarcinoma after treatment of hepatolithiasis: immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma. lnt J Cancer 1993; 55:82–91.

    Google Scholar 

  23. Chapman RW. Risk factors for biliary tract carcinogenesis. Annals of Oncology 1999; 10 Suppl. 4:s308–311.

    Article  Google Scholar 

  24. Schwartz DA: Cholangiocarcinoma associated with liver fluke infection: a preventable source of morbidity in Asian immigrants. Am J Gastroeneterol 81:76, 1986.

    CAS  Google Scholar 

  25. Kurathong S, Lerdverasirikul P, Wonkpaitoon V, et al: Opisthorchis viverrini infection and cholangiocarcinoma. A prospective, case-controlled study. Gastroenterology 89: 151, 1985.

    PubMed  CAS  Google Scholar 

  26. Sell S, Dunsford HA: Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. Am J Pathol 134:1347,1989.

    PubMed  CAS  Google Scholar 

  27. Baserga R, Yokoo H, Henengar GC. Thorotrast-induced cancer in man. Cancer 1960; 13:1021–6.

    Article  PubMed  CAS  Google Scholar 

  28. Ito Y, Kojiro M, Nakashima T, et al. Pathomorphologic characteristics of 102 cases of Thorotrast-related hepatocellular carcinoma, cholangiocarcinoma, and hepatic angiosarcoma. Cancer 1988; 62:1153–8.

    Article  PubMed  CAS  Google Scholar 

  29. Janower ML, Miettinen OS, Flynn MJ. Effects of long-term Thorotrast exposure. Radiology 1972; 103:13–20.

    PubMed  CAS  Google Scholar 

  30. Piehler JM, Crichlow RW. Primary carcinoma of the gallbladder. Surg Gynecol Obstet 1978: 147: 929.

    PubMed  CAS  Google Scholar 

  31. Levin B. Gallbladder carcinoma. Annals of Oncology 10 Suppl. 4: S129–S130, 1999.

    Article  Google Scholar 

  32. Krain LS: Carcinoma of the gallbladder in California, 1955–1969. J Chronic Dis 25:65, 1972.

    Article  PubMed  CAS  Google Scholar 

  33. Maibenco DC, Smith JL, Nava HR, Petrelli NJ, Douglass HO. Carcinoma of the Gallbladder. Cancer Investigation 16(1), 33–39 (1998).

    Article  PubMed  CAS  Google Scholar 

  34. Polk HC: Carcinoma and the calcified gallbladder. Gastroenterology 50:582–585, 1966.

    PubMed  Google Scholar 

  35. Berk RN, Armbuster TG, Salzstein SL: Carcinoma in the porcelain gallbladder. Radiology 106:29–31, 1973.

    PubMed  CAS  Google Scholar 

  36. Black WC. The morphogenesis of gallbladder carcinoma. In Progress in Surgical Pathology. Masson, New York: Fonoglio CM, Wolff M (eds), 1980:207.

    Google Scholar 

  37. Kimura K, Ohto M, Saisho H, Unozawa T, Tsuchiya Y, Morita M, Ebara M, Matsutani S, Okuda K: Association of gallbladder carcinoma and anomalous pancreaticobiliary ductal union. Gastroenterology 89: 1258–1265, 1985.

    PubMed  CAS  Google Scholar 

  38. Suda K, Miyano T, Konuma I, et al. An abnormal pancreatico-choledochoductal junction in cases of biliary tract carcinoma. Cancer 1983;52:2086–8.

    Article  PubMed  CAS  Google Scholar 

  39. Yamauchi S, Koga A, Matsumoto S, et al. Anomalous junction of pancreaticobiliary duct without congenital choledochal cyst: a possible risk factor for gallbladder cancer. Am J Gastroenterol 1987; 82:20–6.

    PubMed  CAS  Google Scholar 

  40. Fortner JG: Carcinoma of the gallbladder: The experimental induction of primary cancer. Cancer 8:689, 1955.

    Article  PubMed  CAS  Google Scholar 

  41. Fortner JG, Leffall LD: Carcinoma of the gallbladder in dogs. Cancer 14:1127, 1961.

    Article  PubMed  CAS  Google Scholar 

  42. Kowalewski K, Todd EF: Carcinoma of the gallbladder induced in hamsters by insertion of cholesterol pellets and feeding dimethylnitrosamine. Pros Soc Exp Biol Med 136:482, 1971.

    CAS  Google Scholar 

  43. Mancuso TF, Brennan MJ: Epidemiological consideration of cancer of the gallbladder, bile ducts and salivary glands in the rubber industry. J Occup Med 12:333, 1970.

    PubMed  CAS  Google Scholar 

  44. Kozuka S, Tsubone M, Yasui A, et al. Relation of adenoma to carcinoma in the gallbladder. Cancer 1982; 50:226–34.

    Article  Google Scholar 

  45. Yamagiwa H. Mucosal dysplasia of gallbladder: isolated and adjacent lesions to carcinoma. Jpn J Cancer Res 1989; 80:238–45.

    Article  PubMed  CAS  Google Scholar 

  46. Koichi W, Masao T, Koji Y, et al. Carcinoma and polyps of the gallbladder associated with Peutz-Jeghers syndrome. Dig Dis Sci 1987; 32:943–6.

    Article  Google Scholar 

  47. Jones RS. Carcinoma of the Gallbladder. Surg Clin of North Am 1990:70(6) 1419–28.

    CAS  Google Scholar 

  48. Piehler JM, Crichlow: Primary carcinoma of the gallbladder. Surg Gynecol Obstet 147:929, 1978.

    PubMed  CAS  Google Scholar 

  49. Hanks JB, Arnold WS. Hepatic Neoplasms. Surgery. Scientific Principles and Practice. Philadelphia, PA: Lippincott-Raven, Greenfield, et al. (2nd edition) 1997: 1008–1022.

    Google Scholar 

  50. Roh M. Colorectal Cancer Metastasis to the Liver. Current Surgical Therapy. St. Louis, Missouri: Mosby, Inc, Cameron JL. (6th edition) 1998: 352–354.

    Google Scholar 

  51. Jaffe BM, Donegan WL, Watson F, et al: Factors influencing survival in patients with untreated hepatic metastases. Surg Gynecol Obstet 127:1–11, 1968.

    PubMed  CAS  Google Scholar 

  52. Bengmark S, Hafstrom L: The natural history of primary and secondary maligant tumors of the liver: I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy. Cancer 23:198–202, 1969.

    Article  PubMed  CAS  Google Scholar 

  53. Goslin R, Steele G, Zamcheck N, et al: Factors influencing survival in patients with hepatic metastases from adenocarcinoma of the colon and rectum. Dis Colon Rectum 25:749–754, 1982.

    Article  PubMed  CAS  Google Scholar 

  54. Bengtsson G, Carlsson G, Hafstrom L: Natural history of patients with untreated liver metastases from colorectal cancer. Am J Surg 141: 586–589, 1981.

    Article  PubMed  CAS  Google Scholar 

  55. Finan PJ, Marshall RJ, Cooper EH, et al: Factors affecting survival in patients presenting with synchronous hepatic metastases from colorectal cancer: A clinical and computer analysis. Br J Surg 72:373–377, 1985.

    Article  PubMed  CAS  Google Scholar 

  56. De Brauw LM, De Velde CJH, Bouwhuis-Hoogerwerf ML: Diagnostic evaluation and survival analysis of colorectal cancer patients with liver metastases. J Surg Oncol 34:81–86, 1987.

    Article  PubMed  Google Scholar 

  57. Wood CB, Gillis CR, Blumgart LH: A retrospective study of the natural history of patients with liver metastases from colorectal cancer. Clin Oncol 2:285–288, 1976.

    PubMed  CAS  Google Scholar 

  58. Wagner JS, Adson MA, Van Heerde JA, et al: The natural history of hepatic metastases from colorectal cancer: A comparison with resective treatment. Ann Surg 199:502–508, 1984.

    Article  PubMed  CAS  Google Scholar 

  59. Fong Y: Hepatic Colorectal Metastasis: Current Surgical Therapy, Selection Criteria for Hepatectomy, and Role for Adjuvant Therapy. Advances in Surgery 34:351–373, 2000.

    PubMed  CAS  Google Scholar 

  60. Scheele J: Liver resection for colorectal metastases. World J Surg 19:59–71, 1995.

    Article  PubMed  CAS  Google Scholar 

  61. Fong Y, Fortner JG, Sun R, et ai: Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: Analysis of 1001 consecutive case. Ann Surg 230:309–321, 1999.

    Article  PubMed  CAS  Google Scholar 

  62. Hughes KS, Simon R, Songhorabodi S, et al: Resection of the liver for colorectal carcinoma metastases: A multi-institutional study of patterns of recurrence. Surgery 100:278–284, 1986.

    PubMed  CAS  Google Scholar 

  63. Scheele J, Stangl R, Altendorf-Hofman A, et al: Indicators of prognosis after hepatic resection for colorectal secondaires. Surgery 110:13–29, 1991.

    PubMed  CAS  Google Scholar 

  64. Rosen CB, Nagorney DM, Taswell HF, et al: Perioperative blood transfusion and determinants of survival after liver resection for metastatic colorectal carcinoma. Ann Surg 216:492–505, 1992.

    Article  Google Scholar 

  65. Gayowski TJ, Iwatsuki S, Madariaga JR, et al: Experince in hepatic resection for metastasic colorectal cancer: Analysis of clinical and pathological risk factors. Surgery 116:703–711, 1994.

    PubMed  CAS  Google Scholar 

  66. Fong Y, Cohen AM, Fortner JG, et al: Liver resection for colorectal metasrases. J Clin Oncol 15:93 8–946, 1997.

    Google Scholar 

  67. Nordlinger B, Jeack D, Gulget M, et al: in Nordlinger B (ed): Surgical Resection of Hepatic Metastases: Multicentric Retrospective Study by the French Association Surgery. Paris, Springer, 1992, pp 129–146.

    Google Scholar 

  68. Moertel CG. Karnofsky Memorial Lecture: an odyssey in the land of small tumors. J Clin Onc 1987; 5:1503–1522.

    Google Scholar 

  69. Shebani KO, Souba WW, Finkelstein, et al. Prognosis and survival in patients with gastrointestinal tract carcinoid tumors. Ann Surg 1999:229:815–823.

    Article  PubMed  CAS  Google Scholar 

  70. Norheim I, Oberg K, Eheodorsson-Norheim E, et al. Malignant carcinoid tumors. Ann Surg 1987; 206:115–125.

    Article  PubMed  CAS  Google Scholar 

  71. Chamberlain RS, Canes D, Brown KT, Saltz L, Jarnigan W, Fong Y and Blumgart L. Hepatic neuroendocrine metastases: does intervention alter outcomes? J Am Coll Surg 2000: 432–445.

    Google Scholar 

  72. McEntee Gp, Nagorney Dm, Kvoils LK, et al. Cytoreductive hepatic surgery for neuroendocrine tumors. Surgery 1990; 108:1091–1096.

    PubMed  CAS  Google Scholar 

  73. Martin JK, Moertel CG, Adson MA, et al. Surgical treatment of functioning metastatic carcinoid tumors. Arch Surg 1983; 118: 537–542.

    Article  PubMed  Google Scholar 

  74. Moertel CG, Johnson M, McKusick MA, et al. The Management of Patients with Advanced Carcinoid Tumors and Islet Cell Carcinomas. Ann Intern Med. 1994; 120:302–309.

    PubMed  CAS  Google Scholar 

  75. Que FG, Nagorney DM, Batts KP, Linz LJ, Kvols LK. Hepatic resection for neuroendocrine carcinomas. Am J Surg 1995; 169:36–42.

    Article  PubMed  CAS  Google Scholar 

  76. Dousset B, Saint-Marc O, Pitre J, Soubrane O, Houssin D, Chapuis Y. Metastatic endocrine tumors: medical treatment, surgical resection, or liver transplantation. World J Surg. 20, 908–915, 1996.

    Article  PubMed  CAS  Google Scholar 

  77. Söreide O, Berstad T, Bakka A, et al. Surgical treatment as a principle in patients with advanced abdominal carcinoid tumors. Surgery 1992;111:4854.

    Google Scholar 

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  1. Northwestern University Medical School, Chicago, IL, USA

    Sam G. Pappas M.D., Jacqueline S. Jeruss M.D. & Mark S. Talamonti M.D.

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    Mark S. Talamonti M.D.  & Sam G. Pappas M.D.  & 

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Pappas, S.G., Jeruss, J.S., Talamonti, M.S. (2001). Clinical Features of Primary and Metastatic Hepatic Malignancies. In: Talamonti, M.S., Pappas, S.G. (eds) Liver-Directed Therapy for Primary and Metastatic Liver Tumors. Cancer Treatment and Research, vol 109. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3371-6_1

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  • DOI: https://doi.org/10.1007/978-1-4757-3371-6_1

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