Abstract
Tumors arise from single cells that develop into large populations sharing a series of genetic alterations. The single phenotypic feature that best characterizes a transformed cell is its ability to proliferate indefinitely when left undisturbed.1 The recognition of specific genes that modulate proliferation, has led to studies on the cell cycle.2 Homeostasis has a great importance in the development of tumors and is regulated by a balance among proliferation, the arrest of growth and programmed death (apoptosis).
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Tortora, V. et al. (1999). Regulation of p53 Function in Normal and Malignant Cells. In: Zappia, V., Della Ragione, F., Barbarisi, A., Russo, G.L., Iacovo, R.D. (eds) Advances in Nutrition and Cancer 2. Advances in Experimental Medicine and Biology, vol 472. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3230-6_9
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DOI: https://doi.org/10.1007/978-1-4757-3230-6_9
Publisher Name: Springer, Boston, MA
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