Genetic Immunization against Tumors

  • Constantin A. Bona
  • Adrian I. Bot


There is not yet a unified theory that explains the poor immunogenicity of most tumors for essentially two reasons: First, genetic instability of tumoral cells allows the emergence and selection of mutant cells that may evade immunity; second, there is a tremendous heterogeneity in the mechanisms responsible for immune system evasion by tumor cells, including tolerance of tumor antigens that may not be discriminated from self-antigens.


Tumor Antigen Tumor Challenge Genetic Immunization Genetic Vaccine P815 Tumor Cell 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Constantin A. Bona
    • 1
  • Adrian I. Bot
    • 2
  1. 1.Mount Sinai School of MedicineNew YorkUSA
  2. 2.Alliance Pharmaceutical Corp.San DiegoUSA

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