Endovascular Chemotherapy Delivery

  • Dat Nguyen
  • Stanley R. Klein


The earliest account of a substance used as an antineoplastic agent in humans was by Adair and Bagg in 1931.1 This first substance was dichloroethylsulfide, a sulfur mustard. It was locally applied as a vesicant to eradicate malignant tumors. Both sulfur and nitrogen mustard were heavily investigated under military secrecy during World War II as potential chemical-warfare agents.2 One of the most important observations by Gilman and Phillips was the destruction or shrinkage of lymphoid tissues shortly after administration of a “toxic dose of nitrogen mustard.”2 With wide availability of nitrogen mustards to civilian investigators in 1946, many physicians found them to be therapeutically useful in palliative treatment of lymphomas and leukemia but with significant local and systemic toxic effects.3 Administration of nitrogen mustard into peripheral veins was noted to produce an intense local inflammatory reaction, causing pain and frequently resulting in thrombosis and occlusion. Significant systemic toxic effects, particularly on the gastrointestinal tract and hemopoietic system, were also noted.


Inferior Vena Cava Central Venous Catheter Internal Jugular Vein Superior Vena Cava Subclavian Vein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Suggested Reading

  1. Bauer GM, Porter JM, Fletcher WS: Human umbilical cord vein allograft arteriovenous fistula for chemotherapy access, Am J Surg 138: 238–240, 1979.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Dat Nguyen
  • Stanley R. Klein

There are no affiliations available

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