Refinement of the Model Structure

  • Jan Drenth
Part of the Springer Advanced Texts in Chemistry book series (SATC)

Abstract

From isomorphous replacement or molecular replacement an approximate model of the protein structure can be obtained in which the broad features of the molecular architecture are apparent. Structure factors calculated on the basis of this model are generally in rather poor agreement with the observed structure factors. The agreement index between calculated and observed structure factors is usually represented by an R-factor as defined in Eq. (13.1). Thus an R-factor of 50% is not uncommon for the starting model, whereas for a random acentric structure it would be 59% (Wilson, 1950).

Keywords

Phase Angle Refinement Technique Isotropic Temperature Factor Peptide Plane Calculated Structure Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Jan Drenth
    • 1
  1. 1.Laboratory of Biophysical ChemistryGroningenThe Netherlands

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