Skip to main content

Abstract

The human oral cavity contains several types of epithelial surfaces and is the only site in the body that contains hard non-shedding natural surfaces (on teeth) for microbial colonization. Teeth are composed of four tissues: pulp, dentine, cementum and enamel. Dentine is the major component of the tooth: it supports the outer highly calcified enamel and protects the inner pulp, which contains nerve cells and blood supply. Cementum covers the roots of the tooth. Teeth possess a number of distinct surfaces that may be colonized by microorganisms. Pits and fissures on the biting (occlusal) surfaces frequently carry large populations of bacteria. Smooth surfaces are more exposed to environmental cleansing forces and tend to be colonized by a more limited number of bacteria. When recession of the gingival (gum) tissues occurs, as it does with natural aging, the cementum may become exposed and then colonized by microorganisms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Banas, J. A., Russell, R. R. B. and Ferretti, J. J. (1990) Sequence analysis of the gene for the glucan-binding protein of Streptococcus mutons Ingbritt. Infection and Immunity, 58, 667–673.

    PubMed  CAS  Google Scholar 

  • Beighton, D. and Lynch, E. (1995) Comparison of selected microflora of plaque and underlying carious dentine associated with primary root caries lesions. Caries Research, 29, 154–158.

    Article  PubMed  CAS  Google Scholar 

  • Bowden, G. H., Ekstrand, J., McNaughton, B. et al. (1990) The association of selected bacteria with the lesions of root surface caries. Oral Microbiology and Immunology, 5, 346–351.

    Article  PubMed  CAS  Google Scholar 

  • Brady, L. J., Piacentini, D. A., Crowley, P. J. et al. (1992) Differentiation of salivary agglutinin-mediated adherence and aggregation of mutans streptococci by use of monoclonal antibodies against the major surface adhesin P1. Infection and Immunity, 60, 1008–1017.

    PubMed  CAS  Google Scholar 

  • Challacombe, S. J. (1980) Serum and salivary antibodies to Streptococcus mutans in relation to the development and treatment of human dental caries. Archives of Oral Biology, 25, 495–502.

    Article  PubMed  CAS  Google Scholar 

  • Cisar, J. O., David, W. A., Curl, S. H. et al. (1984) Exclusive presence of lactose-sensitive fimbriae on a typical strain (WVU45) of Actinomyces naeslundii. Infection and Immunity, 46, 453–458.

    CAS  Google Scholar 

  • Cisar, J. O., Barsumian, E. L., Siraganian, R. P. et al. (1991) Immunochemical and functional studies of Actinomyces viscosus T14V type 1 fimbriae with monoclonal and polyclonal antibodies directed against the fimbrial subunit. Journal of General Microbiology, 137, 1971–1979.

    Article  PubMed  CAS  Google Scholar 

  • Clark, W. B., Beem, J. E., Nesbitt, W. E. et al. (1989) Pellicle receptors for Actino- myces viscosus type 1 fimbriae in vitro. Infection and Immunity, 57, 3003–3008.

    CAS  Google Scholar 

  • Colby, S. M., Whiting, G. C., Tao, L. et al. (1995) Insertional inactivation of the Streptococcus mutans dexA (dextranase) gene results in altered adherence and dextran catabolism. Microbiology, 141, 2929–2936.

    Article  PubMed  CAS  Google Scholar 

  • Cvitkovitch, D. G., Boyd, D. A. and Hamilton, I. R. (1995) Regulation of sugar uptake via the multiple sugar metabolism operon by the phosphoenolpyruvatedependent sugar phosphotransferase transport system of Streptococcus mutans, in Genetics of Streptococci, Enterococci and Lactococci, (eds J. J. Ferretti, M. S. Gilmore, T. R. Klaenhammer and F. Brown), Developments in Biological Standardization, vol. 85, S. Karger, Basel, pp. 351–356.

    Google Scholar 

  • Demuth, D. R., Duan, Y., Brooks, W. et al. (1996) Tandem genes encode cell-surface polypeptides SspA and SspB which mediate adhesion of the oral bacterium Streptococcus gordonii to human and bacterial receptors. Molecular Microbiology, 20, 403–413.

    Article  PubMed  CAS  Google Scholar 

  • Drucker D. B., Shakespeare, A. P. and Green, R. M. (1984) The production of dental plaque and caries by the bacterium Streptococcus salivarius in gnotobiotic WAG/RIJ rats. Archives of Oral Biology, 6, 437–443.

    Article  Google Scholar 

  • Duan, Y., Fisher, E., Malamud, D. et al. (1994) Calcium-binding properties of SSP5, the Streptococcus gordonii M5 receptor for salivary agglutinin. Infection and Immunity, 62, 5220–5226.

    PubMed  CAS  Google Scholar 

  • Ellwood, D. C. and Hamilton, I. R. (1982) Properties of Streptococcus mutans Ingbritt growing on limited sucrose in a chemostat: repression of the phosphoenolpyruvate phosphotransferase transport system. Infection and Immunity, 36, 576–581.

    PubMed  CAS  Google Scholar 

  • Ferretti, J. J., Gilpin, M. L. and Russell, R. R. B. (1987) Nucleotide sequence of a glucosyltransferase gene from Streptococcus sobrinus MFe28. Journal of Bacteriology, 169, 4271–4278.

    PubMed  CAS  Google Scholar 

  • Frandsen, E. V. G., Pedrazzoli, V. and Kilian, M. (1991) Ecology of viridans streptococci in the oral cavity and pharynx. Oral Microbiology and Immunology, 6, 129–133.

    Article  PubMed  CAS  Google Scholar 

  • Gibbons, R. J. and Hay, D. I. (1988) Human salivary acidic proline-rich proteins and statherin promote the attachment of Actinomyces viscosus LY7 to apatitic surfaces. Infection and Immunity, 56, 439–445.

    PubMed  CAS  Google Scholar 

  • Gibbons, R. J. Hay, D. I. and Schlesinger, D. H. (1991) Delineation of a segment of adsorbed salivary acidic proline-rich proteins which promotes adhesion of Streptococcus gordonii to apatitic surfaces. Infection and Immunity, 59, 2948–2954.

    CAS  Google Scholar 

  • Giffard, P. M. and Jacques, N. A. (1994) Definition of a fundamental repeating unit in streptococcal glucosyltransferase glucan-binding regions and related sequences. Journal of Dental Research, 73, 1133–1141.

    PubMed  CAS  Google Scholar 

  • Gilmore, K. S., Russell, R. R. B. and Ferretti, J. J. (1990) Analysis of the Streptococcus downei gtfS gene, which specifies a glucosyltransferase that synthesizes soluble glucans. Infection and Immunity, 58, 2452–2458.

    PubMed  CAS  Google Scholar 

  • Harrington, D. J. and Russell, R. R. B. (1993) Multiple changes in cell wall antigens of isogenic mutants of Streptococcus mutans. Journal of Bacteriology, 175, 5925–5933.

    CAS  Google Scholar 

  • Hassell, T. M. and Harris, E. L. (1995) Genetic influences in caries and periodontal diseases. Critical Reviews in Oral Biology and Medicine, 6, 319–342.

    Article  PubMed  CAS  Google Scholar 

  • Hawkins, B. W., Cannon, R. D. and Jenkinson, H. F. (1993) Interactions of Actinomyces naeslundii strains T14V and ATCC 12104 with saliva, collagen and fibrinogen. Archives of Oral Biology, 38, 533–535.

    Article  PubMed  CAS  Google Scholar 

  • Hillman, J. D., Chen, A. and Snoep, J. L. (1996) Genetic and physiological analysis of the lethal effect of L-(+)-lactate dehydrogenase deficiency in Streptococcus mutans: complementation by alcohol dehydrogenase from Zymomonas mobilis. Infection and Immunity, 64, 4319–4323.

    CAS  Google Scholar 

  • Homer, K. A., Kelley, S., Hawkes, J. et al. (1996) Metabolism of glycoproteinderived sialic acid and N-acetylglucosamine by Streptococcus oralis. Microbiology, 142, 1221–1230.

    CAS  Google Scholar 

  • Hudson, M. C. and Curtiss III, R. (1990) Regulation of expression of Streptococcus mutans genes important to virulence. Infection and Immunity, 58, 464 470.

    Google Scholar 

  • Jenkinson, H. F. (1992) Adherence, coaggregation, and hydrophobicity of Streptococcus gordonii associated with expression of cell surface lipoproteins. Infection and Immunity, 60, 1225–1228.

    PubMed  CAS  Google Scholar 

  • Jenkinson, H. F. (1994a) Adherence and accumulation of oral streptococci. Trends in Microbiology, 2, 209–212.

    Article  PubMed  CAS  Google Scholar 

  • Jenkinson, H. F. (1994b) Cell surface protein receptors in oral streptococci. FEMS Microbiology Letters, 121, 133–140.

    Article  PubMed  CAS  Google Scholar 

  • Jenkinson, H. F. (1995) Genetic analysis of adherence by oral streptococci. Journal of Industrial Microbiology, 13, 186–192.

    Article  Google Scholar 

  • Jenkinson, H. F. and Demuth, D. R. (1997) Structure, function and immunogenicity of streptococcal antigen I/II polypeptides. Molecular Microbiology, 23, 183–190.

    Article  PubMed  CAS  Google Scholar 

  • Kelly, C. G., Todryk, S., Kendal, H. L. et al. (1995) T-cell, adhesion, and B-cell epitopes of the cell surface Streptococcus mutans protein antigen I/II. Infection and Immunity, 63, 3649–3658.

    PubMed  CAS  Google Scholar 

  • Kilian, M., Reinholdt J., Lomholt H., et al. (1996) Biological significance of IgAl proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence. Acta Pathologica Microbiologica et Immunologica Scandinavica, 104, 321–338.

    Article  CAS  Google Scholar 

  • Kiska, D. L. and Macrina, F. L. (1994) Genetic regulation of fructosyltransferase in Streptococcus mutans. Infection and Immunity, 62, 1241–1251.

    CAS  Google Scholar 

  • Klier, C. M., Kolenbrander, P. E., Roble, A. G. et al. (1997) Identification of a 95kDa putative adhesin from Actinomyces serovar WVA963 strain PK1259 that is distinct from type 2 fimbrial subunits. Microbiology, 143, 835–846.

    Article  PubMed  CAS  Google Scholar 

  • Koga, T., Okahashi, N., Takahashi, I. et al. (1990) Surface hydrophobicity, adherence, and aggregation of cell surface protein antigen mutants of Streptococcus mutans serotype c. Infection and Immunity, 58, 289–296.

    PubMed  CAS  Google Scholar 

  • Kuramitsu, H. J. (1993) Virulence factors of mutans streptococci: role of molecular genetics. Critical Reviews in Oral Biology and Medicine, 4, 159–176.

    PubMed  CAS  Google Scholar 

  • Lamont, R. J., Demuth, D. R., David, C. A., et al. (1991) Salivary-agglutininmediated adherence of Streptococcus mutans to early plaque bacteria. Infection and Immunity, 59, 3446–3450.

    PubMed  CAS  Google Scholar 

  • Lamont, R. J., Gil, S., Demuth, D. R. et al. (1994) Molecules of Streptococcus gordonii that bind to Porphyromonas gingivalis. Microbiology, 140, 867–872.

    CAS  Google Scholar 

  • Lawry, J. and Switalski, L. M. (1996) Cloning and expression of collagen adhesin of Streptococcus mutans. Journal of Dental Research (IADR Abstracts), 75, 96, abstr. 626.

    Google Scholar 

  • LeBlanc, D. J. (1994) Role of sucrose metabolism in the cariogenicity of the mutans streptococci, in Molecular Genetics of Bacterial Pathogenesis, (eds V. L. Miller, J. B. Kaper, D. A. Portnoy and R. R. Isberg ), American Society for Microbiology, Washington, DC, pp. 465–477.

    Google Scholar 

  • Lee, S. F., Progulske-Fox, A., Erdos, G. W. et al. (1989) Construction and characterization of isogenic mutants of Streptococcus mutans deficient in major surface protein antigen P1 (antigen I/II). Infection and Immunity, 57, 3306–3313.

    PubMed  CAS  Google Scholar 

  • Lehner, T., Challacombe, S. J. and Caldwell, J. (1975) Immunological and bacteriological basis for vaccination against dental caries in rhesus monkeys. Nature (London), 254, 517–520.

    Article  CAS  Google Scholar 

  • Lehner, T., Russell, M. W. and Caldwell J. (1980) Immunisation with a purified protein from Streptococcus mutans protects against dental caries in rhesus monkeys. Lancet, i, 995–996.

    Google Scholar 

  • Li, Y. and Caufield, P. W. (1995) The fidelity of initial acquisition of mutans streptococci by infants from their mothers. Journal of Dental Research, 74, 681–685.

    Article  PubMed  CAS  Google Scholar 

  • Ligtenberg, A. J. M., Walgreen-Weterings, E., Veerman, E. C. I. et al. (1992) Influence of saliva on aggregation and adherence of Streptococcus gordonii HG 222. Infection and Immunity, 60, 3878–3884.

    PubMed  CAS  Google Scholar 

  • Liu, T., Gibbons, R. J., Hay, D. I. et al. (1991) Binding of Actinomyces viscosus to collagen: association with the type 1 fimbrial adhesin. Oral Microbiology and Immunology, 6, 1–5.

    Article  PubMed  Google Scholar 

  • Ma, J. K.-C., Hunjan, M., Smith, R. et al. (1990) An investigation into the mechanism of protection by local passive immunization with monoclonal antibodies against Streptococcus mutons. Infection and Immunity, 58, 3407–3414.

    CAS  Google Scholar 

  • McGrady, J. A., Butcher, W. G., Beighton, D. et al. (1995) Specific and charge interactions mediate collagen recognition by oral lactobacilli. Journal of Dental Research, 74, 649–657.

    Article  PubMed  CAS  Google Scholar 

  • McNab, R. and Jenkinson, H. F. (1992) Gene disruption identifies a 290 kDa cell-surf ace polypeptide conferring hydrophobicity and coaggregation properties in Streptococcus gordonii. Molecular Microbiology, 6, 2939–2949.

    Article  CAS  Google Scholar 

  • McNab, R., Holmes, A. R., Clarke, J. M. et al. (1996) Cell surface polypeptide CshA mediates binding of Streptococcus gordonii to other oral bacteria and to immobilized fibronectin. Infection and Immunity, 64, 4204–4210.

    PubMed  CAS  Google Scholar 

  • McNab, R., Jenkinson, H. F., Loach, D. M. et al. (1994) Cell-surface-associated polypeptides CshA and CshB of high molecular mass are colonization determinants in the oral bacterium Streptococcus gordonii. Molecular Microbiology, 14, 743–754.

    Article  CAS  Google Scholar 

  • Mandel, I. D. (1996) Caries prevention: current strategies, new directions. Journal of the American Dental Association, 127, 1477–1488.

    PubMed  CAS  Google Scholar 

  • Marsh, P. D. (1994) Microbial ecology of dental plaque and its significance in health and disease. Advances in Dental Research, 8, 263–271.

    PubMed  CAS  Google Scholar 

  • Matsushita, K., Nisizawa, T., Nagaoka, S. et al. (1994) Identification of antigenic epitopes in a surface protein antigen of Streptococcus mutans in humans. Infection and Immunity, 62, 4034 4042.

    Google Scholar 

  • Moisset, A., Schatz, N., Lepoivre, Y. et al. (1994) Conservation of salivary glycoprotein-interacting and human immunoglobulin G-cross-reactive domains of antigen I/II in oral streptococci. Infection and Immunity, 62, 184–193.

    PubMed  CAS  Google Scholar 

  • Munro, C. L., Michalek, S. M. and Macrina, F. L. (1995) Sucrose-derived exopolymers have site-dependent roles in Streptococcus mutans-promoted dental decay. FEMS Microbiology Letters, 128, 327–332.

    Article  PubMed  CAS  Google Scholar 

  • Murray, P. A., Prakobphol, A., Lee, T. et al. (1992) Adherence of oral streptococci to salivary glycoproteins. Infection and Immunity, 60, 31–38.

    PubMed  CAS  Google Scholar 

  • Nesbitt, W. E., Beem, J. E., Leung, K.-P. et al. (1992) Isolation and characterization of Actinomyces viscosus mutants defective in binding salivary proline-rich proteins. Infection and Immunity, 60, 1095–1100.

    PubMed  CAS  Google Scholar 

  • Ofek, I., Kahane, I. and Sharon, N. (1996) Toward anti-adhesion therapy for microbial diseases. Trends in Microbiology, 4, 297–299.

    Article  PubMed  CAS  Google Scholar 

  • Pearce, C., Bowden, G. H., Evans, M. et al. (1995) Identification of pioneer viridans streptococci in the oral cavity of human neonates. Journal of Medical Microbiology, 42, 67–72.

    Article  PubMed  CAS  Google Scholar 

  • Poy, F. and Jacobson, G. R. (1990) Evidence that a low-affinity sucrose phosphotransferase activity in Streptococcus mutons GS-5 is a high-affinity trehalose uptake system. Infection and Immunity, 58, 1479–1480.

    PubMed  CAS  Google Scholar 

  • Roos, S., Aleljung, P., Robert, N. et al. (1996) A collagen binding protein from Lactobacillus reuteri is part of an ABC transporter system. FEMS Microbiology Letters, 144, 33–38.

    Article  PubMed  CAS  Google Scholar 

  • Russell, R. R. B. (1993) The application of molecular genetics to the microbiology of dental caries. Caries Research, 28, 69–82.

    Article  Google Scholar 

  • Russell, M. W., Harrington, D. J. and Russell, R. R. B. (1995) Identity of Streptococcus mutans surface protein antigen III and wall-associated protein antigen A. Infection and Immunity, 63, 733–735.

    PubMed  CAS  Google Scholar 

  • Russell, M. W. and Lehner, T. (1978) Characterisation of antigens extracted from cells and culture fluids of Streptococcus mutans serotype c. Archives of Oral Biology, 23, 7–15.

    Article  PubMed  CAS  Google Scholar 

  • Russell, R. R. B., Peach, S. L., Colman, G. et al. (1983) Antibody responses to antigens of Streptococcus mutans in monkeys (Macaca fascicularis) immunized against dental caries. Journal of General Microbiology, 129, 865–875.

    PubMed  CAS  Google Scholar 

  • Russell, R. R. B., Shiroza, T., Kuramitsu, H. K. et al. (1988) Homology of glucosyltransferase gene and protein sequences from Streptococcus sobrinus and Streptococcus mu tans. Journal of Dental Research, 67, 543–547.

    Article  CAS  Google Scholar 

  • Scannapieco, F. A. (1994) Saliva-bacterium interactions in oral microbial ecology. Critical Reviews in Oral Biology and Medicine, 5, 203–248.

    PubMed  CAS  Google Scholar 

  • Scannapieco, F. A., Torres, G. I. and Levine, M. J. (1995) Salivary amylase promotes adhesion of oral streptococci to hydroxyapatite. Journal of Dental Research, 74, 1360–1366.

    Article  PubMed  CAS  Google Scholar 

  • Schneewind, O., Fowler, A. and Faull, K. F. (1995) Structure of the cell wall anchor of surface proteins in Staphylococcus aureus. Science, 268, 103–106.

    CAS  Google Scholar 

  • Senpuku, H., Miyauchi, T., Hanada, N. et al. (1995) An antigenic peptide inducing cross-reactive antibodies inhibiting the interaction of Streptococcus mutans PAc with human salivary components. Infection and Immunity, 63, 4695–4703.

    PubMed  CAS  Google Scholar 

  • Shimamura, A., Nakano, Y. J., Mukasa, H. et al. (1994) Identification of amino residues in Streptococcus mutans glucosyltransferases influencing the structure of the glucan product. Journal of Bacteriology, 176, 4845–4850.

    PubMed  CAS  Google Scholar 

  • Simpson, C. L., Giffard, P. M. and Jacques, N. A. (1995) Streptococcus salivarius ATCC 25975 possesses at least two genes coding for primer-independent glucosyltransferases. Infection and Immunity, 63, 609–621.

    CAS  Google Scholar 

  • Slee, A. M. and Tanzer, J. M. (1982) Sucrose transport by Streptococcus mutons: evidence for multiple transport systems. Biochimica et Biophysica Acta, 692, 415–424.

    Article  PubMed  CAS  Google Scholar 

  • Smith, D. J. and Taubman, M. A. (1996) Experimental immunization of rats with a Streptococcus mutans 59-kilodalton glucan-binding protein protects against dental caries. Infection and Immunity, 64, 3069–3073.

    PubMed  CAS  Google Scholar 

  • Smith, D. J., Taubman, M. A. and Ebersole, J. L. (1978) Effects of local immunization with GTF fractions from Streptococcus mutons on dental caries in hamsters caused by homologous and heterologous serotypes of Streptococcus mutans. Infection and Immunity, 21, 833–841.

    Google Scholar 

  • Strömberg, N. and Borén, T. (1992) Actinomyces tissue specificity may depend on differences in receptor specificity for Ga1NAcß-containing glycoconjugates. Infection and Immunity, 60, 3268–3277.

    Google Scholar 

  • Sulavik, M. C. and Clewell, D. B. (1996) Rgg is a positive regulator of the Streptococcus gordonii gtfG gene. Journal of Bacteriology, 178, 5826–5830.

    PubMed  CAS  Google Scholar 

  • Sun, J.-W., Wanda, S.-Y., Camilli, A. et al. (1994) Cloning and DNA sequencing of the dextranase inhibitor gene (dei) from Streptococcus sobrinus. Journal of Bacteriology, 176, 7213–7222.

    CAS  Google Scholar 

  • Sutcliffe, I. C., Hogg, S. D. and Russell, R. R. B. (1993) Identification of Streptococcus mutons antigen D as the HPr component of the sugar-phosphotransferase transport system. FEMS Microbiology Letters, 107, 67–70.

    Article  PubMed  CAS  Google Scholar 

  • Switalski, L. M., Butcher, W. G., Caufield, P. C. et al. (1993) Collagen mediates adhesion of Streptococcus mutans to human dentin. Infection and Immunity, 61, 4119–4125.

    PubMed  CAS  Google Scholar 

  • Takahashi, I., Okahashi, N., Matsushita, K. et al. (1991) Immunogenicity and protective effect against oral colonization by Streptococcus mutons of synthetic peptides of a streptococcal surface protein antigen. Journal of Immunology, 146, 332–336.

    CAS  Google Scholar 

  • Tanzer, J. M. (1992). Microbiology of dental caries, in Contemporary Oral Microbiology and Immunology, (eds J. Slots and M. A. Taubman ), Mosby/Year Book, St Louis, MO, pp. 377–424.

    Google Scholar 

  • Tao, L., Sutcliffe, I. C., Russell, R. R. B. et al. (1993) Transport of sugars, including sucrose, by the msm transport system of Streptococcus mutons. Journal of Dental Research, 72, 1386–1390.

    Article  CAS  Google Scholar 

  • Taubman, M. A., Holmberg, C. J. and Smith, D. J. (1995) Immunization of rats with synthetic peptide constructs from the glucan-binding or catalytic region of mutans streptococcal glucosyltransferase protects against dental caries. Infection and Immunity, 63, 3088–3093.

    PubMed  CAS  Google Scholar 

  • van Palenstein Helderman, W. H., Matee, M. I. N., van der Hoeven, J. S. et al. (1996) Cariogenicity depends more on diet than the prevailing mutans streptococcal species. Journal of Dental Research, 75, 535–545.

    Article  Google Scholar 

  • Vickerman, M. M., Clewell, D. B. and Jones, G. W. (1991) Ecological implications of glucosyltransferase phase variation in Streptococcus gordonii. Applied and Environmental Microbiology, 57, 3648–3651.

    CAS  Google Scholar 

  • Wexler, D. L., Hudson, M. C. and Burne, R. A. (1993) Streptococcus mutons fructosyltransferase (ftf) and glucosyltransferase (gtfBC) operon fusion strains in continuous culture. Infection and Immunity, 61, 1259–1267.

    CAS  Google Scholar 

  • Whittaker, C. J., Klier, C. M. and Kolenbrander, P. E. (1996) Mechanisms of adhesion by oral bacteria. Annual Review of Microbiology, 50, 513–552.

    Article  PubMed  CAS  Google Scholar 

  • Yeung, M. K. (1995) Construction and use of integration plasmids to generate site-specific mutations in the Actinomyces viscosus T14V chromosome. Infection and Immunity, 63, 2924–2930.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Jenkinson, H.F. (1999). Dental caries. In: Tannock, G.W. (eds) Medical Importance of the Normal Microflora. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3021-0_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-3021-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-4730-7

  • Online ISBN: 978-1-4757-3021-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics