Abstract
Prion diseases or transmissible spongiform encephalopathies (TSE) are neurological disorders caused by transmissible pathogens termed prions [1,2]. While the prototype of all prion diseases, scrapie in sheep and goats, has been known for more than two centuries, a new form of animal prion disease designated bovine spongiform encephalopathy (BSE) has since its first recognition in 1986 developed into an epizootic [7,8]. The emergence of a new variant form of Creutzfeldt-Jakob disease (nvCJD) in young people in the UK has raised the possibility that BSE has spread to humans by dietary exposure [9,10]. This fearful scenario has recently been supported by experimental evidence claiming that the agent causing BSE is indistinguishable from the nvCJD agent [3,4, 11,12].
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Klein, M.A., Aguzzi, A. (1999). Involvement of B-Cells in Peripheral Scrapie Pathogenesis. In: Sibinga, C.T.S., Alter, H.J. (eds) Risk Management in Blood Transfusion: The Virtue of Reality. Developments in Hematology and Immunology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3009-8_11
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DOI: https://doi.org/10.1007/978-1-4757-3009-8_11
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