Involvement of B-Cells in Peripheral Scrapie Pathogenesis

  • M. A. Klein
  • A. Aguzzi
Part of the Developments in Hematology and Immunology book series (DIHI, volume 34)


Prion diseases or transmissible spongiform encephalopathies (TSE) are neurological disorders caused by transmissible pathogens termed prions [1,2]. While the prototype of all prion diseases, scrapie in sheep and goats, has been known for more than two centuries, a new form of animal prion disease designated bovine spongiform encephalopathy (BSE) has since its first recognition in 1986 developed into an epizootic [7,8]. The emergence of a new variant form of Creutzfeldt-Jakob disease (nvCJD) in young people in the UK has raised the possibility that BSE has spread to humans by dietary exposure [9,10]. This fearful scenario has recently been supported by experimental evidence claiming that the agent causing BSE is indistinguishable from the nvCJD agent [3,4, 11,12].


Prion Protein SCID Mouse Prion Disease Bovine Spongiform Encephalopathy Follicular Dendritic Cell 
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Copyright information

© Springer Science+Business Media Dordrecht 1999

Authors and Affiliations

  • M. A. Klein
    • 1
  • A. Aguzzi
    • 1
  1. 1.Institute of NeuropathologyUniversity of ZurichZurichSwitzerland

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