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Epstein-Barr Virus Infection and Infectious Mononucleosis

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Abstract

First detected in African Burkitt’s lymphoma cells in 1964,1 the Epstein-Barr virus (EBV) was identified as the cause of infectious mononucleosis (IM) in 19682 when a laboratory worker developed antibodies to the virus during an episode of IM. Large-scale seroepidemiologic studies subsequently confirmed the role of EBV in IM. EBV has also been implicated as an etiologic factor in undifferentiated nasopharyngeal carcinoma, B cell lymphomas in immunocompromised individuals, and oral hairy leukoplakia.

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References

  1. Epstein MA, Achong BG, Barr YM. Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 1964; 1:702–3.

    Article  PubMed  CAS  Google Scholar 

  2. Henle G, Henle W, Diehl V. Relation of Burkitt’s tumour associated herpes-type virus to infectious mononucleosis. Proc Natl Acad Sci USA 1968;101:94–101.

    Article  Google Scholar 

  3. Cohen JI. Molecular biology of Epstein-Barr virus and its mechanism of B-cell transformation. Ann Intern Med 1993; 118:48–50.

    Article  Google Scholar 

  4. Biggar RJ, Henle W, Fleisher G, Bocker J, Lennette ET, Henle G. Primary Epstein-Barr virus infections in African infants. I. Decline of monoclonal antibodies and time of infection. Int J Cancer 1978;22:239–43.

    Article  PubMed  CAS  Google Scholar 

  5. Biggar RJ, Henle G, Bocker J, Lennette ET, Fleisher G, Henle W. Primary Epstein-Barr virus infections in African infants. II. Clinical and serological observations. Int J Cancer 1978; 22:244–50.

    Article  PubMed  CAS  Google Scholar 

  6. Hoagland RJ. Clinical manifestations. In: Infectious mononucleosis. Orlando, FL: Grune & Stratton, 1967:52–60.

    Google Scholar 

  7. Lambore S, McSherry J, Kraus A. Acute and chronic symptoms of mononucleosis. J Fam Pract 1991;33:33–7.

    PubMed  CAS  Google Scholar 

  8. Hoagland RJ. General features of infectious mononucleosis. In: Glade PR, editor. Infectious mononucleosis. Philadelphia: Lippincott, 1973:3–4.

    Google Scholar 

  9. Straus SE. The chronic mononucleosis syndrome. J Infect Dis 1988;157:405–12.

    Article  PubMed  CAS  Google Scholar 

  10. Van der Horst C, Joncas J, Ahronheim G. Lack of effect of peroral acyclovir for the treatment of acute infectious mononucleosis. J Infect Dis 1991;164:788–92.

    Article  PubMed  Google Scholar 

  11. Morgan AJ, Allison AC, Finerty S, et al. Validation of first-generation Epstein-Barr virus vaccine preparation suitable for human use. J Med Virol 1989;29:74–8.

    Article  PubMed  CAS  Google Scholar 

  12. Durbin WA, Sullivan JL. Epstein-Barr virus infections. Pedi-atr Rev 1994(2);15:63–8.

    Article  CAS  Google Scholar 

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© 1998 Springer Science+Business Media New York

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McSherry, J. (1998). Epstein-Barr Virus Infection and Infectious Mononucleosis. In: Taylor, R.B., David, A.K., Johnson, T.A., Phillips, D.M., Scherger, J.E. (eds) Family Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-2947-4_38

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  • DOI: https://doi.org/10.1007/978-1-4757-2947-4_38

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-2949-8

  • Online ISBN: 978-1-4757-2947-4

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