Ulcerative colitis is initially treated non-surgically and most patients respond favorably. A variety of medications are used including steroids, anti-inflammatory drugs, and immunosuppressive medications. Bowel rest and hyperalimentation are occasionally needed for patients presenting with an acute exacerbation. Steroids are used primarily to control acute flare-ups and once the disease has been brought under control, every attempt should be made to gradually wean the steroids. There is no benefit in long-term steroid therapy. In contrast, anti-inflammatory medications such as sulfasalazine or the aminosalicylate preparations can be used for long-term therapy to keep the disease in remission. Immunosuppressive medications include azathioprim, 6-mercaptopurine, and cyclosporin, and their main benefit comes from their ability to lower the dose of prednisone needed to control the disease.
KeywordsUlcerative Colitis Small Bowel Obstruction Immunosuppressive Medication Ileorectal Anastomosis Toxic Megacolon
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