Production of Radionuclides

  • Gopal B. Saha


In 1896, Becquerel discovered the natural radioactivity in potassium uranyl sulfate. Since then, Pierre and Marie Curie, E. Rutherford, and F. Soddy all made tremendous contributions to the discovery of many other radioactive elements. The work of all these scientists has shown that all elements found in nature with an atomic number greater than 83 (bismuth) are radioactive. Artificial radioactivity was first reported by I. Curie and F. Joliot in 1934. These scientists irradiated boron and aluminum targets with a particles from polonium and observed positrons emitted from the target even after the removal of the α-particle source. This discovery of induced or artificial radioactivity opened up a brand new field of tremendous importance. Around the same time, the discovery of the cyclotron, neutron, and deuteron by various scientists facilitated the production of many more artificial radioactivities. At present, more than 2700 radionuclides have been produced artificially in the cyclotron, the reactor, the neutron generator, and the linear accelerator.


Myocardial Perfusion Imaging Nuclear Reaction Thermal Neutron Target Nucleus Neutron Capture Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Reading

  1. Friedlander G, Kennedy JW, Miller JM. Nuclear and Radiochemistry. 3rd ed. New York: Wiley; 1981.Google Scholar
  2. Gelbard AS, Hara T, Tilbury RS, Laughlin JS. Recent aspects of cyclotron production of medically useful radionuclides. In: Radiopharmaceuticals and Labelled Compounds. Vienna: IAEA; 1973:239.Google Scholar
  3. Poggenburg JK. The nuclear reactor and its products. Semin Nucl Med. 1974; 4:229.PubMedCrossRefGoogle Scholar
  4. Saha GB. Miscellaneous radiotracers for imaging. In: Rayudu GVS, ed. Radiotracers for Medical Applications. Boca Raton, Fla: CRC Press; 1983; 11:119.Google Scholar
  5. Saha GB, Maclntyre WJ, Go RT. Cyclotrons and positron emission tomography for clinical imaging. Semin Nucl Med 1992; 22:150.PubMedCrossRefGoogle Scholar
  6. Silvester DJ. Accelerator production of medically useful radionuclides. In: Radiopharmaceuticals and Labelled Compounds. Vienna: IAEA; 1973; 1:197.Google Scholar
  7. Silvester DJ, Waters SL. Radionuclide production. In Sodd VJ, Allen DR, Hoog-land DR, Ice RD, eds. Radiopharmaceuticals II. New York: Society of Nuclear Medicine; 1979:727.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Gopal B. Saha
    • 1
  1. 1.Department of Nuclear MedicineThe Cleveland Clinic FoundationClevelandUSA

Personalised recommendations